ID   E4XGL3_OIKDI            Unreviewed;      2764 AA.
AC   E4XGL3;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CBY09811.1};
GN   ORFNames=GSOID_T00010626001 {ECO:0000313|EMBL:CBY09811.1};
OS   Oikopleura dioica (Tunicate).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC   Oikopleuridae; Oikopleura.
OX   NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY09811.1};
RN   [1] {ECO:0000313|EMBL:CBY09811.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21097902; DOI=10.1126/science.1194167;
RA   Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA   Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA   Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA   Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA   Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA   Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA   Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA   Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA   Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA   Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA   Roest Crollius H., Wincker P., Chourrout D.;
RT   "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT   pelagic tunicate.";
RL   Science 330:1381-1385(2010).
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DR   EMBL; FN653048; CBY09811.1; -; Genomic_DNA.
DR   InParanoid; E4XGL3; -.
DR   Proteomes; UP000001307; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   Gene3D; 1.20.1440.180; KEN domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR045133; IRE1/2-like.
DR   InterPro; IPR010513; KEN_dom.
DR   InterPro; IPR038357; KEN_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR13954; IRE1-RELATED; 1.
DR   PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF06479; Ribonuc_2-5A; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS51392; KEN; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   DOMAIN          1919..2185
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          2175..2330
FT                   /note="KEN"
FT                   /evidence="ECO:0000259|PROSITE:PS51392"
FT   REPEAT          2449..2481
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          20..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         1946
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   2764 AA;  310383 MW;  B960C4A1796CBDCE CRC64;
     MRIDEHFLRA TTALQSRISR SDGKRREERG AGFKRTRGDS KVDSVDGKRM RAGQVRRXXX
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     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXIL ELKGKPKKPS PLPKIGEATV
     SQKVLGRGGF GIVYEGLLEG RVVAVKRQKL EENTKKQIQR EIEVLCHFEH KNICRYYHSQ
     SKTIDGQEHL DIFMKKYDLD LKQLILNKTN LKAPSMAEKR KLLKEIVDGI AYLHSSHQKK
     EKIIHRDLKP ENILILIEND SYSCALSDFG FSKITKAGGN SIANTTNSYH GTLAYSAPET
     LSNSGGKFQK TSEKSDIYSL GLIIYFVLTG GEHPFGNDLS KTLQGKEPTL DAVSDSVFKQ
     LLGTMLKQDR NERISVDGII VHPAFFDEAE KLDYIEKCYE MLKNANEKTI QLMDYEFDKL
     DWREEICPNL RKENLGHMRR GRFVDQYQRT FVDLVKAIRN KSAHFNEFCR DLCNSETPTV
     FSGNSLNKEL FCNYWIGKFP QIIPILYSFL AFSFPNSTEE SNFLNEFYGN HENLEIIQRY
     CYNAYSCAEI KMITKEETSA VFQNLKENKI CVMSASSSTE KLWKLSFKLK LKQSCKVFNE
     IEKEEKVSAF DFRCADCQVA VGYESGLTWI YDSEGREIHN LKGTDKQGES SHTEKVLTIR
     WSPDGILVAS GGKDGRICVW DRKNGKYGVI RCSQQDVEGY AKDIYWCSES QFIISVGHFT
     ILKIFVTSNQ NVDRVNLSHQ KVDLRSSDPS SICPIADEFK KLSDKADKTS LEPSSGLLST
     LSQNGRIHVW SLPSQIDQRY HIHTTLPPAE TWCNSQPKNQ KQAIRCIFSP SSKIIYLASV
     SNICLRLWSF QFDDNLQLQV KKFPPENPIL TFTASDSCST ISAFSFSPCA RYFVYAHNFS
     VSILFLKAAS LQPFKLFYSP EQMRIDGFEW HTSSTKLYFW GKNGAYLIDL SAVAEFRDAH
     MSTF
//