ID E4XH71_OIKDI Unreviewed; 1067 AA.
AC E4XH71;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Peptidase S8/S53 domain-containing protein {ECO:0000259|Pfam:PF00082};
GN ORFNames=GSOID_T00010841001 {ECO:0000313|EMBL:CBY10019.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY10019.1};
RN [1] {ECO:0000313|EMBL:CBY10019.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FN653050; CBY10019.1; -; Genomic_DNA.
DR AlphaFoldDB; E4XH71; -.
DR InParanoid; E4XH71; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43806:SF7; MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1067
FT /note="Peptidase S8/S53 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003192954"
FT TRANSMEM 1019..1040
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 243..499
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 252
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 283
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 447
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1067 AA; 120965 MW; 72B367B6DFE6F9B0 CRC64;
MTLFHFLPLY ICLLTTALAD TIRTSDPIAI VDITVKPCSS CLPQTSTAIA LTVYNAEDLR
KSVLEWRRKR SKQQQEKLGE HENSESEISI KAVDDQWLVI FDGYYSQEHR HKVILTALSG
QHVEIVARDN PAAVFESDFD VLLWPYDERK KLESLLDEHE DIKEVKQQKQ ISRKLQYIKS
QDTYLPSEAR VHRAGQRKPQ SVSSSDYWFG SEKLRSRKLM RSVVKPVTDE LQADILWDLG
FTGAGIKVAI FDTGLPKNHP HFRNVKDRTN WTNEKSLDDG LGHGTFVAGI IASSAECMGF
APDADVHVYR VFTNQQVSYT SWFLDAFNYA ILSQDVLNLS IGGPDFMDTP FVDKVWEMSA
NGIIMISAIG NDGPLYGTLN NPADQMDVIG VGGTDFAHNI AKFSSRGMTT WELPAGYGRV
KPDIVTYGSS VRGSGIYSGC RTLSGTSVAS PVVAGVVTLL YSTVPEEKRH FVNPASMKQA
LMHGAKRIDG TNMFEQGAGR VDLIQSWKIL KSYKPQATLS PPYIDFMDCP YMWPYCSQSL
FHTGMPTIAN VTILNAISVS SKIVGIPIWR PYDQETGHFV DISVSHSSVI WPWTGYIALT
IMINEKGAEF EGIISGHLEF FVHSKNDDNN EDIEENVVIS EMKLPLRISV IPTPKRWQRV
LWDQFHNLRY PPGYFPRDNL KMKNDPLDWN GDHIHTNFRD LYERLRAAGY FIDVLGESFN
CFDASNYGTL MIVDSEEEFF AEEIEKIAKD VEGGLNLIVF GDWFNTEVMK KVRFFDENTR
QWWIPDTGGA NVPALNELLE PFEIGLGDIV SDGEFEFSER KMNFASGTSL VQFPDQGKVL
VRNLRDQGAD ILRNEKDETF KPKENTVAIF GVHEYKLGKV AVYGDSNCID GAHMQKECYW
LVEELLQYFR TELFAEELVS DLVEWSAVKE QFESFSTLPE RFVGNQLHRF SKVLVPGLSM
KNKPIPECRE LTFLTPQYLN DSKSTLSWKN RPLLSIDWEE ENLEIQSYKP LPLSHPETFS
SATVFIVFSA CGAALLFLLA QMRSRKNERS QKPLKFSKSR SNKNLST
//
