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Database: UniProt
Entry: E4XHL7_OIKDI
LinkDB: E4XHL7_OIKDI
Original site: E4XHL7_OIKDI 
ID   E4XHL7_OIKDI            Unreviewed;       398 AA.
AC   E4XHL7;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CBY10165.1};
GN   ORFNames=GSOID_T00010996001 {ECO:0000313|EMBL:CBY10165.1};
OS   Oikopleura dioica (Tunicate).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC   Oikopleuridae; Oikopleura.
OX   NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY10165.1};
RN   [1] {ECO:0000313|EMBL:CBY10165.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21097902; DOI=10.1126/science.1194167;
RA   Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA   Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA   Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA   Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA   Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA   Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA   Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA   Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA   Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA   Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA   Roest Crollius H., Wincker P., Chourrout D.;
RT   "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT   pelagic tunicate.";
RL   Science 330:1381-1385(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + propanoyl-CoA = 2-methyl-3-oxobutanoyl-CoA + CoA;
CC         Xref=Rhea:RHEA:30719, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:57335, ChEBI:CHEBI:57392;
CC         Evidence={ECO:0000256|ARBA:ARBA00036841};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30720;
CC         Evidence={ECO:0000256|ARBA:ARBA00036841};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:30721;
CC         Evidence={ECO:0000256|ARBA:ARBA00036841};
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR   EMBL; FN653051; CBY10165.1; -; Genomic_DNA.
DR   AlphaFoldDB; E4XHL7; -.
DR   InParanoid; E4XHL7; -.
DR   Proteomes; UP000001307; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020613; Thiolase_CS.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR18919:SF156; ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00737; THIOLASE_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003557}.
FT   DOMAIN          13..269
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          278..397
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        97
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        356
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        384
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   398 AA;  41349 MW;  857B09F5DFE7A4D3 CRC64;
     MLGKVISRSL HDVVIVSASR TPMGSFQSSL SSMSATQLGS VAIKDAVEKA GIEGSVVEES
     YIGNVSQAHQ GQAPARQATL GAGLPNTIPC TTINKVCASG TKAVMMAAQS LALGHNQCMI
     AGGMESMSNV PYAMKRASPA YGGVKMDDLI VHDGLTDAYN HCHMGVCGEN TASNLDISRA
     EQDAYAISSY HKSAAAWEAG KFNAEICPVI IPGKRGKPDT TVSVDEEYTR FNEAKFGNLR
     AAFKKDGTIT AGNASSLNDG ACALVMMTAE RAKELGVTPL ARVRGYADAA TQPIDFPIAP
     AYATPKALKW AGVSKDDVSQ WEINEAFSVV VLANQKMLDI DPAKINPNGG AVSIGHPIGM
     SGARIVAHLV HNLEAGQLGC ASICNGGGGA AAIVIEKL
//
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