ID E4Y8W1_OIKDI Unreviewed; 3055 AA.
AC E4Y8W1;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Cytoplasmic dynein 2 heavy chain 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSOID_T00029292001 {ECO:0000313|EMBL:CBY43693.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY43693.1};
RN [1] {ECO:0000313|EMBL:CBY43693.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; FN654329; CBY43693.1; -; Genomic_DNA.
DR Proteomes; UP000011014; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 7.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF352; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF07728; AAA_5; 1.
DR Pfam; PF12774; AAA_6; 2.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}.
FT DOMAIN 13..173
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 516..901
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 931..974
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 975..1063
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1097..1231
FT /note="ATPase dynein-related AAA"
FT /evidence="ECO:0000259|Pfam:PF07728"
FT DOMAIN 1572..1774
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 1814..2145
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2171..2320
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 2528..2633
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 2662..2782
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 2808..3052
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1862..1883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2060..2115
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2312..2345
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1869..1883
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3055 AA; 341406 MW; 7AD86DA86BB7F2DD CRC64;
MIYSFWQEGI ARNIQKLGEA VNSESIATRA KERYQKEQTR RLELFHQWQE DIQDETDDMI
IDFDQKSDVF HFNENTKKLE LSFSDRWESL LCEVKQIHAL GLPVNMKVQQ NCRKAARFYR
AGVLLHQVAS FYNSIGSKMI PSTKPMLLKK AIEFEALIKN IAKNEKQMKW ENPDELEKFA
RSLQACSEDF KQANDQIIQK HNELKKLVLE LLNTDLMRQE DKWKGIVSGL REKVENVRVV
HGADQCEAWL IHWDRQLYKV IDVHYKYSLQ TLVDRLPEIE LDLIFNGAGL CFRPDLETAR
TRFYGHIKRI TNLPQSFRGL GPERDLFPRI ALTNAEALVP AYQRAEGIFH KVETILESHA
EWISPAVVDL DSVFSPLKSV KDFEDALREI KQKGKEAEKL REIIKHDCIT VSLTQFKRQV
DGLITRCFNE LCASIKNLVI EESKELNKFI SDSKEALTAR VNSIDDITQQ QLKYHEITKQ
LSSSMKTKYE EMKELMKLHQ NITREEVYIG NLQSDWEGFG IIIDSYEAST EDKVEQLKST
TLEQKKTLSG RIEAVLAKWN SGKPTDTVDS LNDNAKIKNI SSFITEKAEE MRTLSEEIEK
MDKQLVERGT SVDKLKLSSL LDKSKELNDS SIQEKLKRIN ERAHVEISIR ESLAEVELWA
GGTEFSFLEA RDSTGKQVHL IKDWSDLLGE LGDQERLIST LKESPHSINF TDAIALWEKK
LSTTNQVISI FCEIQRKWLY LEPVFCKGVF ATEKSQFMST HSNIVSLLSQ AFHMKTAVSF
STTNGLVDNL ERILQKLQAS QRALSSFLEE KRNSFSKFFF LGDDDLLEIL GRPLSIQTHL
RKLFAGIAAL EIQDESHVMG VKSLGGEKVN LSRNVTIDDN PENWLGQVDA LAKDVLKGYL
RDVVKQMTDE NCKSVDDWVW LKQLRFYSKG DKCFLTLTQA LSLGLGGNPY GPAGTGKTES
VKELGSLLGR HVEIVLSAVS MDIQNIQTAL MKKAKAVSLQ NIDNELSSHT AIFVTLNPAG
KGYGGRRKLP DNLKALFRPV AMSKPDITTI ATVMLFAEGF QEQSLKKVCD TEGIYFYPEF
ARKCLELSEQ LEQRIGVVVC GPPSSGKSVL WKTLGDAFAP EKGSLKIHYM NPKAVSRERL
LGKMDPDTRE WTDGILTAAA RQVNRELEHH HWIVCDGEID PDWIEALNSV LDDNRLLTLP
NGERIQFGNN VNFLFETADL RHASPATISR MGVIFLSTEE IDAFKIASSV IGKLAPTESV
KTEAMQWSKA ILLRDLTMTV GASGNLQAPS ASHDGEIIAT KSLLANSESL KHWISSGVRG
VSLLGNDGCG KSLLVKYCQG QFPSCNFVEM NCSSMSNPSE LVAIIESVGI IGQGKNGRVI
RPKGFDQAII LVRGINIPQK DKWGTNMLYA FLTQLISRGG FYNEEREFVS IEKFKFIFTS
NTSRGQVDMR LSSIVQTLVL EVPNDKEVQK ICKNFWKTSF PNGPYEDMAS STARAFSNLT
AQLGPKEAPH YNLSLSHLNQ WAKACATMES EMFFPKGDGR LHAMDIKDLQ KRLQETSGNF
EREIRDLPTG GLVLSTQLTQ SIVSVTSQLS NKGGNIVLIG PSGSGRRTAV QLGAYSLHFD
VMSPSVTNVS DKAVKNFFRS ALGAASIENK PVVILIESHH LENGQIFVYA NSLLAQGTVP
GLWSTEEIDQ SQLRAEAAAI SMSAMDLFVK RAKENIRLVL SLETGTKALS DCWNQCPALT
KKSKVIVLQR WSHETLRAVA NKRLSLGEAT ETISGHSVEL HKDHGWNPAQ YAVFLKAISE
IYDNKKNSFT ERTEKLQTGL KKLAEAGKTV AELEKDVVEQ QKVLKEKREE ADAALQAIQE
AMGGAETQKD EMSQRKRDAD KERENINKRK AKIEAELSEV QPLIDEAKEA IGGIKTSSLN
EIRALRAPPE VIRDILEGVL KLMGNDDTSW TGMKQFLGKR GVKDDIREFD ARNTPPSSRE
AVEALMQKKA KSFQADVAKR ASVVAAPLAA WVTANVQYAA VLERIAPLEQ EEQKLLRGLR
AAELQVEKLG SGIATVEERV AVLRGEFEQK TSEAARLENR LEDANKRLQK AGKLIKDLSK
EKSRWKEGLK SLQTTQVQLP IQSLLAAAHI VYLSCRHEVE RNKIFTDWKP RYDCQDFKLL
EFLSTEAKLL QYHHKGMPND QLSLENTESL MSFSKTPMLI DQSGRAQSFL KSYFAEQKIE
SVDEHSDAFQ SSVELALRFG KTLMIENITR LSSFLVEVLK ANVHTIGTRP SIKISDKVID
INPNFKLLLA SKTLSYADLP SLSELEEKMT TLVNLQSSKK SAKEIKQTLD ENSRIKEELA
IERNKYSPLA ASAATSFFHI QDIQSLDNMY TTGLHCITVI FDHILKKYHQ KPVEKLRSEF
IKLVVSFVQN MTSKDHEVPA LLHLVAALFQ REFPSQNWFN IMSPGDREFS QKLAAGEREL
SSWLASEYPE NESPKGGNFS KVEQMAVIAQ RRPDRFAASV SNFISRIADL PESGLGAMEF
ISQVGGAATP KLFILSGGAD PTNDIAGLAE AQGQALVEAA LEEDNDATFA VFKECLRSGK
WLLLKNCHLA SSWLEKLEGD LAAPDIHEDF RLWLTSESVP SFSPAILRRS MKMCVEAPPG
LRRSMERISD LWPSRMSSDH LQLALLHSLI LERKGFGSLG WSQEYDFTVA DIRAALAVSA
KMRNRPGITE KMLEGVIYGS RMHNPFDGNL LKLMVNETMS REGPSFGKFP KMISVKSKAD
ALSYTAKLPA SRNSDHLGLA KNSGKALAEH LVRESIRSLN LLARQTEHAD SQWESAAANV
VKHFQKLFSR SSIEAISSLD STQSSPQPIE SFLIGEKRLL KSVFKTVNES INSMEAALRG
SVTSKAKTDA QAILDAATPS SWARAYADGP EEPIAFLDKL AKIMNYLISS ASSSSLNVSM
MFRPSALIAA LQLHENAPAN AVLSLSTSGG KLKVAGIVLS GADFRSKLSH ADINTKSTVE
LPPMGVTFVE ETSAAMPLYS DQHRENLICP AILSGLGSDA SPWLLSGAAL FLSSV
//
