ID E4YEU7_OIKDI Unreviewed; 1443 AA.
AC E4YEU7;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Multiple epidermal growth factor-like domains protein 6 {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSOID_T00022012001 {ECO:0000313|EMBL:CBY34034.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY34034.1};
RN [1] {ECO:0000313|EMBL:CBY34034.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; FN654469; CBY34034.1; -; Genomic_DNA.
DR Proteomes; UP000011014; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR Gene3D; 2.10.25.10; Laminin; 10.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 6.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR042635; MEGF10/SREC1/2-like.
DR PANTHER; PTHR24043:SF6; -; 1.
DR PANTHER; PTHR24043; SCAVENGER RECEPTOR CLASS F; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00053; Laminin_EGF; 5.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 29.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM00180; EGF_Lam; 17.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 11.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS01187; EGF_CA; 4.
DR PROSITE; PS50027; EGF_LAM_2; 1.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1443
FT /note="Multiple epidermal growth factor-like domains
FT protein 6"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003191075"
FT DOMAIN 26..107
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 106..140
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 183..219
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 394..434
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 532..567
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 575..610
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 869..904
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 964..1012
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1005..1035
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 130..139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 557..566
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 600..609
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 894..903
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 982..991
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1025..1034
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1443 AA; 154561 MW; DDB100DE3FDB2C23 CRC64;
MKMRPVQLAL AAAALAQQAT ELRPSDANVC SSTQIVKKQK RQPVVKQADR TKKVWKKNCP
NGQRWCIDYE TTKVFYTTFE QVTVDEEVTV YSCCAGWAQG SEAGCTVQVC GAGACFHGGF
CSKDGTTCIC KNGWTGTRCE RDINECEVGN GQCSHQCCNL VGSYKCSCPQ GWLLLSDERT
CADIDECQER NGGCAHQCHN VDGGYQCTCD AGYKLHNDQR SCLPTNRCAR DNGNCAQKCI
VLNEHSFKCD CEEGYVLSEN GRNCELEDPC LRDNGHCQHN CQSVGQQAVC SCDTGFKLDK
DGQKCIDADE CVHNNGGCSG ICTNTEGSFF CSCQDGYDVG EDGFTCYKVV IELISRKKPG
RDGCQHSCSE DSGEAICKCR NGFQLEIDGK SCRDVDECAT GRHKCQHQCR NIIGSYECSC
RVGFAIARDG VSCEDVNECY DQNGGCDQIC NNAQGTYTCA CGGGFVLDRD GRSCSRIDNS
EYSSHTSSSI TFSSYDYRSK EDNNSTIVRR YLNTQPDLLT GILIERCAPG NFGENCKLTC
NNCEHGACTD MADGCICEPG WQGELCDEKC DKDHFGDNCE FRCQCENGGT CDHVTGECKC
PTGVFGDFCE DGCPAGRWGE ECEKRCKCGP GGGRCNRKFG ACFCAPGRYG KNCHLRCPKF
TFGSGCTEKC SCNKRRSFGC DPVSGKYTCA IGTYGRSCAR KCKCAEGVHC HPRSGRCVRK
CPPGRQGLKC QKICSEGYFG QNCQQKCSCS KKNASGCNAG SGKCLCKAGF HGSDCSRPCP
AGFFGMGCKS KCTCLNGTCN SEDGSCICSA GFTGPNCERS CHLGTYGQGC AETCHCQGSA
PCDPITGSCL CAAGKTGTYC DRDCPQGTYG VGCAQTCFCQ NGAKCDPISG ACSCAPGYHG
VVCERPCPDG FWGMSCQNNC NCGNSGSHCD HVTGLCTCSV GYYGDDCLQV CPSGSFGENC
QQICSCGEGA TSCDPFTGEC QCKSGFTGLK CDKFCERGSW GLRCENRCNC RNSGTCDAQT
GVCQCADGWM GSKCELPCQD GYYGAGCSRT CGCLNGGKCD GDGRCTCLEG YVGDQCQSPC
EDGNWGLQCK NKCKCENGAS NSCDNENGKC KCLPGWRGDH CEIACLPGYF GEGCAQKCTC
KSNEPCHHIT GQCSCPPGQT GYGCHRVCPN GRFGRDCSQM CACTHENSEC SPVDGTCSCS
SGWSGNECEE ECPEGRWGPN CSEVCLCSDG ICDSVTGQCR TCAPGHIGPD CEQRCTSYFW
GSNCAQVRTW GVSCLQQCQC GNGGSCDAAT GSCSCGVGLT GPTCSRPCPD GTWGSSCKNI
CHCQWRNTEK CHAVNGRCYC KAGMTGDHCT EECADGRWGR GCQSRCDCGG YLCDKENGKC
FCPPGFMGPK CNTECTGGNY GPNCSLPCQC EHSSYCAGDT GRCHCRPGWG GPRCQVRISY
ITR
//