ID E4YHJ8_OIKDI Unreviewed; 1371 AA.
AC E4YHJ8;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=beta-mannosidase {ECO:0000256|ARBA:ARBA00012754};
DE EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
DE AltName: Full=Mannanase {ECO:0000256|ARBA:ARBA00033445};
GN ORFNames=GSOID_T00025015001 {ECO:0000313|EMBL:CBY34972.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY34972.1};
RN [1] {ECO:0000313|EMBL:CBY34972.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC in beta-D-mannosides.; EC=3.2.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000829};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ALG6/ALG8 glucosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00008715}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
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DR EMBL; FN654569; CBY34972.1; -; Genomic_DNA.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000011014; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0004567; F:beta-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR041625; Beta-mannosidase_Ig.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR004856; Glyco_trans_ALG6/ALG8.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF03155; Alg6_Alg8; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF17753; Ig_mannosidase; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 2.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 662..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 713..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 751..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 779..802
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 822..844
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 865..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 893..912
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 933..954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 960..977
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 989..1006
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1018..1038
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 270..320
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 1300..1363
FT /note="Beta-mannosidase Ig-fold"
FT /evidence="ECO:0000259|Pfam:PF17753"
SQ SEQUENCE 1371 AA; 156712 MW; 5D55572D3BE84331 CRC64;
MLFLFFFIAF ADCFSISSIN SSNLTFTAEK KLLSCSNLPP VTIYSCFLSK FPSENINNRT
NDANLQWIGT TKSSFEAEFG QIKPAKFAFL QLENVDTIGE IIWNGAKIGN VRNSFRKYLF
DVSKTINPTN QLQIDLQAPV IAAKQAAEAQ YPIKQYPECP VSAQTNGQCH VNMLRKPQYS
FSWDWGPSMP DSGIYDSPKL LVFDSSAIFD AKLQLLSAFS DDLQILQVQV LILHPNSESA
PAGQAIVNFK PALKFSEDAM KFEKVDENLW KGTMNLQIER EEINWWWIHG MGKQNLYTAT
ITWDSSSSEI SSIEKQFGFR TAELVQDQLQ DGLSFYFKIN EKPTFMSGSN WIPSSSYIGD
FSDYYADNLQ SAVDAGIKML RVWGGGIYEQ DAFYSKANEL GLLIWQDFTF ACSTYENDDA
FLDSVAKEVS DQIWRLSSNP SIVAWAGNNE NEAALATNWW SIPDEEMDFY YKQYSDLYIN
TAQKTILSEG LTVPFVLSSP SNGKMSENSP NGIAKNPYDP NFGDVHFYDY KSDCTDWTKF
PKTRFASEFG YQSVAKIYEK CFRMDFWDCT GIFLIFSGFK ILLAQKYDLY HSTDFDVHRN
WLAITNSKPI SEWYFENTSE WTLDYPPFFA YFEKLLSKYA AKYDPLLVKI QKDPISTDNV
VFFQKMTVVF TDITVLFGAY FFCKSFNSRK NNLEVAFLIS CNAALFIIDH IHFQYNGLIL
GLLLCFLAAF MNGKLKTAAL VFSFLLHLKH LFLYVAPFAG IAFLQQINST RIRRGIKTAF
LKLAFIASIV LFVSAASLFP FLSQLDQLAA RLFPFKRGLT HSYWAGNFWA IYNFVDLLLA
RLFGMKSALT SGLVGEFSHQ VLPNVPPLAT FSLTFASMIP ALVKIWTKPE RKTWILSFCS
IALSSFIFGW HVHEKAILLA LLPASGFMLL EKSLFRVFGI LMVAGVSGVL PLIFTEFEQS
IVIPVYILYL LTTLYIFQPD FQRMNIIEKL YIISSVPLVA FVQIWSKVLL PSLPFLPLLV
QSLYTALGVL YSFILINLEL FSVDSWGLIS SIESVTSSAD RYFGSAWAAQ RNHHQDGNEQ
IYGFITQFFG EQPWIKNQSE EAFKNFIYLS QTVQSICTSS QANFYRSRAG LQSTMGALYW
QLNDVWSTAS WSSLDYSKNW KPLHYQIKKN FNSELTLISK VNDNDQLEVF VISDYVATKG
RLKVETRSWR SFDTLGEVDY GMFEIKQLEG NLILTKNVGF LLNQMNCPYG KWNECYFTIS
FITNDGLTLF TTWESPVPIR EIKVFTELDA NVAFFGDCSI DPKDQSLEFE ISSALPQPFV
WLETRYIGKW SDNFFMMTSS RSFLTFMPAY ELTCEEFMKD AQIYYPSKVH W
//
