ID E4ZAW7_NEIL0 Unreviewed; 567 AA.
AC E4ZAW7;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=TLDD protein homolog {ECO:0000313|EMBL:CBN86494.1};
GN Name=tldD {ECO:0000313|EMBL:CBN86494.1};
GN OrderedLocusNames=NLA_2530 {ECO:0000313|EMBL:CBN86494.1};
OS Neisseria lactamica (strain 020-06).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=489653 {ECO:0000313|EMBL:CBN86494.1, ECO:0000313|Proteomes:UP000008723};
RN [1] {ECO:0000313|EMBL:CBN86494.1, ECO:0000313|Proteomes:UP000008723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=020-06 {ECO:0000313|EMBL:CBN86494.1,
RC ECO:0000313|Proteomes:UP000008723};
RX PubMed=21092259; DOI=10.1186/1471-2164-11-652;
RA Bennett J.S., Bentley S.D., Vernikos G.S., Quail M.A., Cherevach I.,
RA White B., Parkhill J., Maiden M.C.;
RT "Independent evolution of the core and accessory gene sets in the genus
RT Neisseria: insights gained from the genome of Neisseria lactamica isolate
RT 020-06.";
RL BMC Genomics 11:652-652(2010).
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
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DR EMBL; FN995097; CBN86494.1; -; Genomic_DNA.
DR AlphaFoldDB; E4ZAW7; -.
DR KEGG; nla:NLA_2530; -.
DR eggNOG; COG0312; Bacteria.
DR HOGENOM; CLU_026425_1_0_4; -.
DR Proteomes; UP000008723; Chromosome.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR30624:SF4; METALLOPROTEASE TLDD; 1.
DR PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 125..187
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 214..322
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 330..557
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 567 AA; 61149 MW; 2F0D4062C9296D35 CRC64;
MGGAVRKRER KPERAGKVCF LRRHYPDRFY GFCFRNLSRP AAALRQERLK FTQSNVRWQN
SYISGTTAHF HNKCRIIKPL IFLCADTMHP TYSAVRERLL EANRLSPELL AKSLGIIGAH
HVDYADIYCQ RTAYESWHLE EGIVKSGSFQ IDQGVGVRAV SGDKTAFAYA DSLCINSINR
SARAVRAIGT AGGKVSAKMP SETRGKPVCS ASDPIAGLDS AAKVVLLNKV EAIAKAADPR
IVQVMAGLTC EYDMVYLARL DGKHAADIRP MVRLNVTVIA RQGERREQGS AGGGGRYDLA
YFDENLVHRF VDAAVKQALT NLESRPAPAG EMTVVLGNGW PGVLLHEAVG HGLEGDFNRK
GTSVFSGRIG ERVAAKGVTV VDQGDIAGRR GSLNIDDEGN ETRRTVLIED GILVGYMQDE
TNARLTGTQS TGNGRRESYA SIPMPRMTNT FMENGGYEPD EIIASIDKGI YAVNFGGGQV
DITSGKFVFS ASEAWWVEGG RLQYPVKGAT IIGNGPEVLK HVSMIGNDTA LDSGVGVCGK
EGQSVPVGVG QPTLRIDAGL TVGGSAI
//
