ID E4ZDE8_NEIL0 Unreviewed; 628 AA.
AC E4ZDE8;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203,
GN ECO:0000313|EMBL:CBN87382.1};
GN OrderedLocusNames=NLA_11610 {ECO:0000313|EMBL:CBN87382.1};
OS Neisseria lactamica (strain 020-06).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=489653 {ECO:0000313|EMBL:CBN87382.1, ECO:0000313|Proteomes:UP000008723};
RN [1] {ECO:0000313|EMBL:CBN87382.1, ECO:0000313|Proteomes:UP000008723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=020-06 {ECO:0000313|EMBL:CBN87382.1,
RC ECO:0000313|Proteomes:UP000008723};
RX PubMed=21092259; DOI=10.1186/1471-2164-11-652;
RA Bennett J.S., Bentley S.D., Vernikos G.S., Quail M.A., Cherevach I.,
RA White B., Parkhill J., Maiden M.C.;
RT "Independent evolution of the core and accessory gene sets in the genus
RT Neisseria: insights gained from the genome of Neisseria lactamica isolate
RT 020-06.";
RL BMC Genomics 11:652-652(2010).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; FN995097; CBN87382.1; -; Genomic_DNA.
DR RefSeq; WP_013449013.1; NC_014752.1.
DR AlphaFoldDB; E4ZDE8; -.
DR KEGG; nla:NLA_11610; -.
DR eggNOG; COG0322; Bacteria.
DR HOGENOM; CLU_014841_3_0_4; -.
DR Proteomes; UP000008723; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW SOS response {ECO:0000256|ARBA:ARBA00023236, ECO:0000256|HAMAP-
KW Rule:MF_00203}.
FT DOMAIN 33..111
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 220..255
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT DOMAIN 274..502
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
SQ SEQUENCE 628 AA; 71037 MW; B11150D38058CFA8 CRC64;
MPSEAVFQII DMNTETRSPE QFDIPLFLKN LPKLPGVYRF FDEGGKVLYV GKAVNLKRRV
SGYFQKNDHS PRIALMVKQV HHIETTVTRS EAEALILENN FIKALSPKYN ILFRDDKSYP
YLMLSGHQYP QMAYYRGTLK KPNQYFGPYP NSNAVRDSIQ VLQKVFMLRT CEDSVFEHRD
RPCLLYQIKR CTAPCVGHIS EEDYRNSVRE AATFLNGKTD ELTRTLQHKM QAAAANLQFE
EAARYRDQIQ ALGIMQSNQF IDSKNPNNPN DIDLLALAVS DGLVCVHWVS IRGGRHVGDK
SFFPDTKNDP EPNGQDYAEA FVAQHYLGKS KPDIIISNFP IPDALKEALE GEHGKQMQFV
TKTIGERKVW LKMAEQNAQM AIAQRRLQQS NRQHRIDELA KILGMDSDGL NRLECFDISH
TQGEATIASC VVYDEQNIQP SQYRRYNITT AKPGDDYAAM REVLTRRYGK MQEAEANGET
VKWPDVVLID GGKGQIGVAV SVWEELGLHI PLVGIAKGPE RKAGMEELIL PFTGEVFRLP
PNSPALHLLQ TVRDESHRFA ITGHRKKRDK ARVTSSLSDI PGIGSKRRQA LLTRFGGLRG
VIAASREDLE KVEGISKALA ETIYNHLH
//