GenomeNet

Database: UniProt
Entry: E4ZDE8_NEIL0
LinkDB: E4ZDE8_NEIL0
Original site: E4ZDE8_NEIL0 
ID   E4ZDE8_NEIL0            Unreviewed;       628 AA.
AC   E4ZDE8;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   24-JAN-2024, entry version 66.
DE   RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203,
GN   ECO:0000313|EMBL:CBN87382.1};
GN   OrderedLocusNames=NLA_11610 {ECO:0000313|EMBL:CBN87382.1};
OS   Neisseria lactamica (strain 020-06).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=489653 {ECO:0000313|EMBL:CBN87382.1, ECO:0000313|Proteomes:UP000008723};
RN   [1] {ECO:0000313|EMBL:CBN87382.1, ECO:0000313|Proteomes:UP000008723}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=020-06 {ECO:0000313|EMBL:CBN87382.1,
RC   ECO:0000313|Proteomes:UP000008723};
RX   PubMed=21092259; DOI=10.1186/1471-2164-11-652;
RA   Bennett J.S., Bentley S.D., Vernikos G.S., Quail M.A., Cherevach I.,
RA   White B., Parkhill J., Maiden M.C.;
RT   "Independent evolution of the core and accessory gene sets in the genus
RT   Neisseria: insights gained from the genome of Neisseria lactamica isolate
RT   020-06.";
RL   BMC Genomics 11:652-652(2010).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000256|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC       Rule:MF_00203}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FN995097; CBN87382.1; -; Genomic_DNA.
DR   RefSeq; WP_013449013.1; NC_014752.1.
DR   AlphaFoldDB; E4ZDE8; -.
DR   KEGG; nla:NLA_11610; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_0_4; -.
DR   Proteomes; UP000008723; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR   Gene3D; 4.10.860.10; UVR domain; 1.
DR   Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   NCBIfam; TIGR00194; uvrC; 1.
DR   PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR   PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF14520; HHH_5; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR   SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR   SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00203};
KW   DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW   Rule:MF_00203};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00203};
KW   Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW   Rule:MF_00203};
KW   SOS response {ECO:0000256|ARBA:ARBA00023236, ECO:0000256|HAMAP-
KW   Rule:MF_00203}.
FT   DOMAIN          33..111
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000259|PROSITE:PS50164"
FT   DOMAIN          220..255
FT                   /note="UVR"
FT                   /evidence="ECO:0000259|PROSITE:PS50151"
FT   DOMAIN          274..502
FT                   /note="UvrC family homology region profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50165"
SQ   SEQUENCE   628 AA;  71037 MW;  B11150D38058CFA8 CRC64;
     MPSEAVFQII DMNTETRSPE QFDIPLFLKN LPKLPGVYRF FDEGGKVLYV GKAVNLKRRV
     SGYFQKNDHS PRIALMVKQV HHIETTVTRS EAEALILENN FIKALSPKYN ILFRDDKSYP
     YLMLSGHQYP QMAYYRGTLK KPNQYFGPYP NSNAVRDSIQ VLQKVFMLRT CEDSVFEHRD
     RPCLLYQIKR CTAPCVGHIS EEDYRNSVRE AATFLNGKTD ELTRTLQHKM QAAAANLQFE
     EAARYRDQIQ ALGIMQSNQF IDSKNPNNPN DIDLLALAVS DGLVCVHWVS IRGGRHVGDK
     SFFPDTKNDP EPNGQDYAEA FVAQHYLGKS KPDIIISNFP IPDALKEALE GEHGKQMQFV
     TKTIGERKVW LKMAEQNAQM AIAQRRLQQS NRQHRIDELA KILGMDSDGL NRLECFDISH
     TQGEATIASC VVYDEQNIQP SQYRRYNITT AKPGDDYAAM REVLTRRYGK MQEAEANGET
     VKWPDVVLID GGKGQIGVAV SVWEELGLHI PLVGIAKGPE RKAGMEELIL PFTGEVFRLP
     PNSPALHLLQ TVRDESHRFA ITGHRKKRDK ARVTSSLSDI PGIGSKRRQA LLTRFGGLRG
     VIAASREDLE KVEGISKALA ETIYNHLH
//
DBGET integrated database retrieval system