ID E4ZYN5_LEPMJ Unreviewed; 713 AA.
AC E4ZYN5;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Sorting nexin MVP1 {ECO:0000256|ARBA:ARBA00014268};
GN ORFNames=LEMA_P108260.1 {ECO:0000313|EMBL:CBX96561.1};
OS Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)
OS (Blackleg fungus) (Phoma lingam).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Leptosphaeriaceae;
OC Plenodomus; Plenodomus lingam/Leptosphaeria maculans species complex.
OX NCBI_TaxID=985895 {ECO:0000313|Proteomes:UP000002668};
RN [1] {ECO:0000313|Proteomes:UP000002668}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8
RC {ECO:0000313|Proteomes:UP000002668};
RX PubMed=21326234; DOI=10.1038/ncomms1189;
RA Rouxel T., Grandaubert J., Hane J.K., Hoede C., van de Wouw A.P.,
RA Couloux A., Dominguez V., Anthouard V., Bally P., Bourras S.,
RA Cozijnsen A.J., Ciuffetti L.M., Degrave A., Dilmaghani A., Duret L.,
RA Fudal I., Goodwin S.B., Gout L., Glaser N., Linglin J., Kema G.H.J.,
RA Lapalu N., Lawrence C.B., May K., Meyer M., Ollivier B., Poulain J.,
RA Schoch C.L., Simon A., Spatafora J.W., Stachowiak A., Turgeon B.G.,
RA Tyler B.M., Vincent D., Weissenbach J., Amselem J., Quesneville H.,
RA Oliver R.P., Wincker P., Balesdent M.-H., Howlett B.J.;
RT "Effector diversification within compartments of the Leptosphaeria maculans
RT genome affected by Repeat-Induced Point mutations.";
RL Nat. Commun. 2:202-202(2011).
CC -!- FUNCTION: Required for vacuolar protein sorting.
CC {ECO:0000256|ARBA:ARBA00002474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; FP929129; CBX96561.1; -; Genomic_DNA.
DR RefSeq; XP_003840040.1; XM_003839992.1.
DR AlphaFoldDB; E4ZYN5; -.
DR STRING; 985895.E4ZYN5; -.
DR EnsemblFungi; CBX96561; CBX96561; LEMA_P108260.1.
DR GeneID; 13290030; -.
DR eggNOG; KOG2273; Eukaryota.
DR HOGENOM; CLU_009058_1_0_1; -.
DR InParanoid; E4ZYN5; -.
DR OMA; SSPWDMP; -.
DR OrthoDB; 45524at2759; -.
DR Proteomes; UP000002668; Genome.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd07597; BAR_SNX8; 1.
DR CDD; cd06866; PX_SNX8_Mvp1p_like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR035704; SNX8/Mvp1_PX.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR47554; SORTING NEXIN MVP1; 1.
DR PANTHER; PTHR47554:SF1; SORTING NEXIN MVP1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000002668};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 340..448
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 713 AA; 78147 MW; EC3EF9C8886D8066 CRC64;
MSLFGEDDVP ARAKQSTSLF DDEPKATGRA GSSLFADDVD AGGDSPWALP TPKKAGRAAL
VRSLLPTSDV PDSYIDAYDA LLDAGNGVGN GVSVSSVKAL VASSGVSSGD QSRILEIVFT
SRQESASLGR NEFNVVFALI GLAQEGEDIT LDSVDERKRN LPVPTVTLPT PSKPDTLAPE
ASPMTQDAAP STPPTPQPQS TEQPTPARSH AAPMRKQSFG VPEADPWGSP DLHRDHSHAS
YTSLPSQSNG ASATAPARTT SQFTTQSSPN SSMQAPVQPS SLGSEGGWGG YNGGGAAPFA
APDLGHGGFG APAANEGGPN PNPELHRSIG RINPASSSSD EVITITALSE KEGMFMFQHR
NYEVASSRRT AKVVRRYSDF VWLLDCLHKR YPFRQLPLLP PKRVATADAS FLEKRRKGLQ
RFTNALVRHP VLNQEQLVVM FLTVPTELAV WRKQANLSVQ EEFTGKTLPP DLEDSLPKTL
PDLFDTVRSG VRRSAETYII LCNMMERLTR RNEGMAAEYL RFSTALCSLA EASQETYAVD
TGDVALLNEG LHATARHLDQ SKQLLEDEAR GWEEGVLEDL KRQRDTLVSV RDMFDRRDKY
AKDNIPYLEK RIANNEAKLQ AIRNKPAEQV KPGEKEKVED AIFKDKESIV AQHARSVFII
ECIRDELLFF QKSQYHVTRL HQDWAQERVK YAELQADNWR ALGEEVESMP SAE
//
