ID E5A0M3_LEPMJ Unreviewed; 899 AA.
AC E5A0M3;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Similar to DNA mismatch repair protein mutS {ECO:0000313|EMBL:CBX97083.1};
GN ORFNames=LEMA_P102140.1 {ECO:0000313|EMBL:CBX97083.1};
OS Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)
OS (Blackleg fungus) (Phoma lingam).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Leptosphaeriaceae;
OC Plenodomus; Plenodomus lingam/Leptosphaeria maculans species complex.
OX NCBI_TaxID=985895 {ECO:0000313|Proteomes:UP000002668};
RN [1] {ECO:0000313|Proteomes:UP000002668}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8
RC {ECO:0000313|Proteomes:UP000002668};
RX PubMed=21326234; DOI=10.1038/ncomms1189;
RA Rouxel T., Grandaubert J., Hane J.K., Hoede C., van de Wouw A.P.,
RA Couloux A., Dominguez V., Anthouard V., Bally P., Bourras S.,
RA Cozijnsen A.J., Ciuffetti L.M., Degrave A., Dilmaghani A., Duret L.,
RA Fudal I., Goodwin S.B., Gout L., Glaser N., Linglin J., Kema G.H.J.,
RA Lapalu N., Lawrence C.B., May K., Meyer M., Ollivier B., Poulain J.,
RA Schoch C.L., Simon A., Spatafora J.W., Stachowiak A., Turgeon B.G.,
RA Tyler B.M., Vincent D., Weissenbach J., Amselem J., Quesneville H.,
RA Oliver R.P., Wincker P., Balesdent M.-H., Howlett B.J.;
RT "Effector diversification within compartments of the Leptosphaeria maculans
RT genome affected by Repeat-Induced Point mutations.";
RL Nat. Commun. 2:202-202(2011).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
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DR EMBL; FP929130; CBX97083.1; -; Genomic_DNA.
DR RefSeq; XP_003840562.1; XM_003840514.1.
DR AlphaFoldDB; E5A0M3; -.
DR STRING; 985895.E5A0M3; -.
DR EnsemblFungi; CBX97083; CBX97083; LEMA_P102140.1.
DR GeneID; 13283340; -.
DR eggNOG; KOG0220; Eukaryota.
DR HOGENOM; CLU_002472_7_3_1; -.
DR InParanoid; E5A0M3; -.
DR OMA; KMTMLYK; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000002668; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002668}.
FT DOMAIN 645..661
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 26..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..899
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 899 AA; 100418 MW; FD1A61804CFF6312 CRC64;
MSQRRRPLTS YSSTASSSYG YYPYGEYNTT TTSRPGTRRG TGRPSTARPR TGASTIARIE
AQNVVCAVAE SRGISPTVGL TFVNLDTAEA VLCQICDSQT YIRTVHKLKV YAPSEILIVS
TAASPKSKLF SIIEESLEDI DSKITLLDRR YWAESTGYEY IHSLAFKENV EAIKISVTGN
YYAVCCAAAA LKYIDLGLGL VFSYHSLRIR YEPSEGSMMI DVSTIYSLEL IQNLQNARSR
DCLFGLLNET LTPMGARLLQ NNVLQPLTDA DVLHTRYAAV DDLTKKEEMF FATRAALKTF
LDADRILTAL IVTPARPTLH TTEQAINQII MLKQFVGTVN PIYEALTGTT STMLNNIREL
CAPENVAPIQ ELINRVINTD TTYAKQPLEL RNQRVYAVRS GVNGLLDVAR TTYKEATEDA
YQHSIELSAE HDIRLDLKYE SARQFYMKIP LSELENKALP PIFTNVVQRK KYIECQTVEL
MKRNQKIAVS HQEVILMSDQ AVEGLIEEVR SHMSIMFKIC EAVALLDMPQ LSETLGIEAG
RHPIKEKIMQ TKYVPNDVYA TQQTRFQVIT GCNMSGKSTY IRSIALMTIM AQIGSYVPAT
YASFPILHQL FARLGMDDNI DTNVSTFAAE MREIAFILRN VDKRSMVIID ELGRGTSTRD
GLAIALAIAE ALVSSRALVW FATHFKDLAT IMSERAGVQN LHLAVEIESE RSMTMLYKAT
QGVVKEAHYG LTLARVVPLP PGVVENATQV AQQLERHMLQ RKQTCATVLR QKRRKLILNL
KEHLLQAHSG VLEGEVLTAW LIELKKEFVN RMTAIEAESA GAQQQLDDSF EHEHEYIDEV
MSDVSDHEES EQSCTPHASQ PLSVGTSSSH SSHMTWTASE STPRAITAST IRAVSENER
//
