ID   E5AF35_LEPMJ            Unreviewed;       751 AA.
AC   E5AF35;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Similar to GTPase-activating protein {ECO:0000313|EMBL:CBY01824.1};
GN   ORFNames=LEMA_P006110.1 {ECO:0000313|EMBL:CBY01824.1};
OS   Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)
OS   (Blackleg fungus) (Phoma lingam).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Leptosphaeriaceae;
OC   Plenodomus; Plenodomus lingam/Leptosphaeria maculans species complex.
OX   NCBI_TaxID=985895 {ECO:0000313|EMBL:CBY01824.1, ECO:0000313|Proteomes:UP000002668};
RN   [1] {ECO:0000313|Proteomes:UP000002668}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8
RC   {ECO:0000313|Proteomes:UP000002668};
RX   PubMed=21326234; DOI=10.1038/ncomms1189;
RA   Rouxel T., Grandaubert J., Hane J.K., Hoede C., van de Wouw A.P.,
RA   Couloux A., Dominguez V., Anthouard V., Bally P., Bourras S.,
RA   Cozijnsen A.J., Ciuffetti L.M., Degrave A., Dilmaghani A., Duret L.,
RA   Fudal I., Goodwin S.B., Gout L., Glaser N., Linglin J., Kema G.H.J.,
RA   Lapalu N., Lawrence C.B., May K., Meyer M., Ollivier B., Poulain J.,
RA   Schoch C.L., Simon A., Spatafora J.W., Stachowiak A., Turgeon B.G.,
RA   Tyler B.M., Vincent D., Weissenbach J., Amselem J., Quesneville H.,
RA   Oliver R.P., Wincker P., Balesdent M.-H., Howlett B.J.;
RT   "Effector diversification within compartments of the Leptosphaeria maculans
RT   genome affected by Repeat-Induced Point mutations.";
RL   Nat. Commun. 2:202-202(2011).
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DR   EMBL; FP929139; CBY01824.1; -; Genomic_DNA.
DR   RefSeq; XP_003845303.1; XM_003845255.1.
DR   AlphaFoldDB; E5AF35; -.
DR   STRING; 985895.E5AF35; -.
DR   EnsemblFungi; CBY01824; CBY01824; LEMA_P006110.1.
DR   GeneID; 13285921; -.
DR   eggNOG; KOG2128; Eukaryota.
DR   HOGENOM; CLU_009455_0_0_1; -.
DR   InParanoid; E5AF35; -.
DR   OMA; EAYMITL; -.
DR   OrthoDB; 24454at2759; -.
DR   Proteomes; UP000002668; Genome.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR   CDD; cd05132; RasGAP_GAPA; 1.
DR   InterPro; IPR000593; RasGAP_C.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR14149:SF17; GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   Pfam; PF03836; RasGAP_C; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF143885; RGC domain-like; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002668}.
FT   DOMAIN          158..373
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   COILED          31..58
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   751 AA;  86640 MW;  664DFC2B1A572728 CRC64;
     MSSHDGSRSV RQSKRYSVTA LYLSMSAKDK ELEIEDDLAR AQKILRELKA KISSQSKKNF
     VLEKDVRYLD SRIALLIQNR MALEEQNEVA DHLADGLELQ EGFFPNDEKT QKYGNLLFLL
     QSEPRHIAHL CRLVSMAEID ALLQTVMFTI YGNQYESREE HLLLTMFQSV LTYQFDNTPD
     YSSLLRANTP VSRMMTTYTR RGPGQSYLKV VLQDSINSLI ELKDLDLEIN PLKVYEKMVT
     ELEIQGNLPP DMPKSVTAEQ AADNEKVQQI IAPRVNMLME IANNFLTTII NGLEETPYGI
     RWICKQIRSL SKRKYPDAQD QTICTLIGGF FFLRFINPAI VTPRSYMLID VLPAENPKRT
     LTYIAKMLQN LANKPSYAKE PYMKSLQPFI HQNKERINKF MLDLCEVQDF YDTLEMDNYV
     ALSKKDLELS ITLNEVYATH SLLERHAAEL AKDDSSHLGV ILQELGPAPP QLPRKENRAI
     NLPLFSKWET PLDDLTAALD ITQEEIFFME AKSTFVMILR SLPSNTSITR RPLRLDRIAE
     AAATTKNDSI MVKKGIRSME LLSQLQELGV IDKEDGFSLL RDEVEQELVH LGSIKEKVIE
     ETRKLEEVFR TIRDHNGFLV GQLETYKSYL HNVRSQSEGK TRKQQKHQVL GPYKFTHQQL
     EREGVIQKSN VPENRRANIY FNFTSPLPGT FVISLHYKGR NRGLLELDLK LDDLLEMQKD
     NQEDLDLEYV QFNVSKVLVL LNKRFARKKG W
//