ID E5BFA0_9FUSO Unreviewed; 1204 AA.
AC E5BFA0;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=FSBG_00278 {ECO:0000313|EMBL:EFS20781.1};
OS Fusobacterium gonidiaformans 3-1-5R.
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae;
OC Fusobacterium.
OX NCBI_TaxID=469605 {ECO:0000313|EMBL:EFS20781.1, ECO:0000313|Proteomes:UP000002975};
RN [1] {ECO:0000313|EMBL:EFS20781.1, ECO:0000313|Proteomes:UP000002975}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3_1_5R {ECO:0000313|EMBL:EFS20781.1,
RC ECO:0000313|Proteomes:UP000002975};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Allen-Vercoe E., Strauss J., Ambrose C., Lander E.,
RA Nusbaum C., Galagan J., Birren B.;
RT "The Genome Sequence of Fusobacterium sp. 3_1_5R.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; GG657971; EFS20781.1; -; Genomic_DNA.
DR RefSeq; WP_008800860.1; NZ_GG657971.1.
DR AlphaFoldDB; E5BFA0; -.
DR HOGENOM; CLU_007510_1_0_0; -.
DR OrthoDB; 32195at2; -.
DR BioCyc; FSP469605-HMP:GTSP-281-MONOMER; -.
DR Proteomes; UP000002975; Unassembled WGS sequence.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR047939; BREX_1_PglX.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF033452; BREX_1_MTaseX; 1.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|EMBL:EFS20781.1};
KW Hydrolase {ECO:0000313|EMBL:EFS20781.1};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nuclease {ECO:0000313|EMBL:EFS20781.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002975};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 297..541
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
SQ SEQUENCE 1204 AA; 140760 MW; 798941AF5F091C0E CRC64;
MNKSNLKKFA IGARQELREK TKAQLKRLGM EEKKIEEGKD MGSQVEIYGK LYSKSSYQHL
LVKYHSLGYE ELVEESAYLW FNRLTALAYM ELHDCFSEHM IFSKGSKGEP SILDEYFQAD
FFQKMPLEKQ EELHQLRDQN TSDSLETLYS ILMEEKCEEL SKIMPFLFSK KGKYADILFP
SGLLMQDSVL KKLQAILLEI QEEDQSIPVE ILGWLYQYYN SEKKDEVFAG LKKNQKVTKE
NIPAATQLFT PHWIVKYMVE NSLGKLILEY IPNMESIKKD WNYYIETEIE SSSEKLSIEG
IKILDPAMGS GHMLTYAFDI LFDVYQELGW SKKESVLSIL QNNLYGLEID DRAGQIAAFA
LLMKGKEKFP RLFQVLEREE NFEMPVISLQ ESNAISKRMY TMLEESPTLQ DLLKGFENAK
EYGSILKIDS FAESILQEEY QKLQEKIQNQ GQFSLLKNNE FLEGDLEEDL ERLERIIRQY
KIMIQKYDVV ITNPPYMGGR GFSPKLKNYT EKNYKDSKSD LFSVFMEVCQ GFTKKNRYTA
MITMQSWMFL SSFETLRNHM ITKTEIQTLN HLGTRAFSEL AGEVVQTVSW VQKHKTPEKK
GTYIRLVDYN NGEEKEREFF NKENYYQANQ KDFTKIPGSP IAYWVSDRIR EIFEKEKKLG
EVGEAKQGLA TADNNRFVRL WHEINFHTIG FGMKNSEEAL NSKKKWFPYN KGGEKRKWYG
NQEYVVNWEK DGYEIKNFKN SVVRNPSYYF KKSISWSDIT SSGNSFRLYP EGFIYDVTGM
SYFIEDKFLT YLGIFNTKIY SKLTKLINPT LHLQIGDMIK MPYFQIQNPL FEQLVSLILW
ISFEEWASRE TSWDFERLTL LNGENLSKAY KKYCTYWESK FFSVHSSEED LNRILLESYS
LQEEMDEKVG FSDITLLKKE ASIVENIDNA TSCGYLENRG AKLEFHSLEL VKQFLSYAIG
CIMGRYSLDK SGLIMANSDD VLSMSSNKIT VSGVNGEIRH EILNPSFFPE EFGILSVTTE
ERFENDIVSR VIAFISAAYG KEHLEENLEF ITEILGKKAG ESHEEVLRNY FIKDFYTDHC
QRYQKRPIYW MLHSGKKNGF SALIYLHRYE ENTIARVRSD YLLPYQDFME QQEAHYSKIA
SDEVSTPTEK KDAQKKVKEL HDILKELKDY ANKVKHIAEQ RISLDLDDGV KVNYEKLGSI
LKKI
//