ID E5DMP3_9TELE Unreviewed; 967 AA.
AC E5DMP3;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Voltage-gated sodium channel type IV alpha subunit Nav1.4a {ECO:0000313|EMBL:ADQ00335.1};
DE Flags: Fragment;
GN Name=scn4aa {ECO:0000313|EMBL:ADQ00335.1};
OS Myomyrus macrops.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Myomyrus.
OX NCBI_TaxID=112156 {ECO:0000313|EMBL:ADQ00335.1};
RN [1] {ECO:0000313|EMBL:ADQ00335.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=#6182 {ECO:0000313|EMBL:ADQ00335.1};
RX PubMed=21127261; DOI=10.1073/pnas.1011803107;
RA Arnegard M.E., Zwickl D.J., Lu Y., Zakon H.H.;
RT "Old gene duplication facilitates origin and diversification of an
RT innovative communication system--twice.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:22172-22177(2010).
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DR EMBL; GU362025; ADQ00335.1; -; mRNA.
DR AlphaFoldDB; E5DMP3; -.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 3.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF223; SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 3.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 3.
PE 2: Evidence at transcript level;
KW Ion channel {ECO:0000313|EMBL:ADQ00335.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 44..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 748..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 807..827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..892
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..207
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 216..420
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 425..698
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 746..938
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 332..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..384
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADQ00335.1"
FT NON_TER 967
FT /evidence="ECO:0000313|EMBL:ADQ00335.1"
SQ SEQUENCE 967 AA; 110053 MW; 30379806C9FF8B01 CRC64;
PMTPNFEHVL TVGNLVFSGI FAGEMVLKII AMDPYYYFQV GWNVFDSIIV TMSMVEMVFA
DVEGLSVLRS FRLPRVFKLA KSWPTPNMLL TIIGNSVGAL GILTVVLAII VFIFAVVGMQ
LFAKNYKDCV CKIAEDCELP RWHMHDFFHS FLIVFRILCG EWIETMWDCM EVADKTMCMV
LFLMVMIIGN LVVLNLFLAL LLSSFSGDNL QMPEDDGELN NLQLSALRIT RAIDWVKAFI
RGLIWKMLGK QPKGEDVLEE KEGEDCCKEA FNMNNMPSEE PRTDFRVLDG LAHWVDDIHP
SGFFLSSDFT FTVPIAREES DLEMLDTDGE DFSTDEELEE DEIPGPKKRV GAPDGVSECS
TVDYVPPPPP PDAEEEEEPE PVEPEACYTE DCLRRCPCLV LDTSQGRGKA WWNLRRTCYT
IVEHDYFETF IIFMILLSSG ALAFEDIYIE RRRTIKIMLE YADKVFTYVF VIEMFLKWVA
YGYQVYFTNS WCWLDFLIVD VSLVSLAASL MGYSELGPIK SLRTLRALRP LRALSRFEGM
RVVVNALVGA VPAIFNVMLV CLIFWLIFSI MGVNLFAGTF YHCLNTTTGE MFTIDVVNNY
SECMALMHTN EVRWANVRVN YDNVGMGYLS LLQVSTFKGW MEIMYAAVDS RKVGQQPSYE
ANLYMYLYFV IFIIFGSFFT LNLFIGVIID NFNQQKNKMG GDCFMTEEQK KYYDAMKKLG
NKKPAKPIPR PQSKIPGLVY DLINKQPFDI FIMVLIVLNM VTMMVESDDQ SQEMTDMLAK
INGVFIVVFS SECFLKMIAL RQYFFTIGWN VFDFVVVIFS VASMLVADLI EKYFVSPTLF
RVVRLARIGR VLRLIKGAKG IRTLLFALMM SLPALFNIGL LLFLVMFIFS IFGMSNFAYV
KKEGGVDDMF NFETFPNSMI CLFEITTSAG WDGLLFPMLI SGPPDCDPDI INPGTDVRGN
CGSPGKA
//
