ID E5DMS1_ELEEL Unreviewed; 906 AA.
AC E5DMS1;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Voltage-gated sodium channel type IV alpha subunit Nav1.4b {ECO:0000313|EMBL:ADQ00363.1};
DE Flags: Fragment;
GN Name=scn4ab {ECO:0000313|EMBL:ADQ00363.1};
OS Electrophorus electricus (Electric eel) (Gymnotus electricus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Gymnotiformes;
OC Gymnotoidei; Gymnotidae; Electrophorus.
OX NCBI_TaxID=8005 {ECO:0000313|EMBL:ADQ00363.1};
RN [1] {ECO:0000313|EMBL:ADQ00363.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21127261; DOI=10.1073/pnas.1011803107;
RA Arnegard M.E., Zwickl D.J., Lu Y., Zakon H.H.;
RT "Old gene duplication facilitates origin and diversification of an
RT innovative communication system--twice.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:22172-22177(2010).
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DR EMBL; GU362053; ADQ00363.1; -; mRNA.
DR AlphaFoldDB; E5DMS1; -.
DR SMR; E5DMS1; -.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 3.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF223; SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 3.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 3.
PE 2: Evidence at transcript level;
KW Ion channel {ECO:0000313|EMBL:ADQ00363.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 725..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 755..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 862..882
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..179
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 187..364
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 370..645
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 694..889
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 223..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADQ00363.1"
FT NON_TER 906
FT /evidence="ECO:0000313|EMBL:ADQ00363.1"
SQ SEQUENCE 906 AA; 103201 MW; ADC2D406B83D1428 CRC64;
IAMDPYYYFQ VGWNIFDSII VTMSLVELGL ANVEGLSVLR SFRLMRVFKL AKSWPTLNML
IKIIGNSVGA LGNLTLVLAI IVFIFAVVGM QLFGKSYKDC VCKIAEDCEL PRWHMNDFFH
SFLIVFRVLC GEWIETMWDC MEVAGQAMCL TVFMMVMVIG NLVVLNLFLA LLLSSFSGDN
LSSSDDDGEM NNLQIAIARI SRGSDWVKAF VIRHIGLKPK EEEKKENDLG DLKGNSGLVR
NHMDSGEEPD SEMRKQVEAF EMAIVPVSRA PIANIESDFE RTIDDDSTDE DENLKDTHSE
ADSSSIGSTV DMHPQAAETE CDEEEDSNSP KDCFTEKCIM RYPCLDVDIT EGRGKIWWNF
RKTCLIIVEH NYFETFIIFM ILLSSGALAF EDVYIEQRRV IKIILEYADQ VFTYIFVVEM
LLKWVAYGFK VYFTNAWCWL DFLIVDVSLI SFTANILGYS DLGPIKSLRT LRALRPLRAL
SRFEGMRVVV NALVGAIPSI FNVMLVCLIF WLIFSIMGVN LFAGKFYYCI NTTSEEVFLI
DEVNNKSDCL TLIQANSDVR WMNTKVNYDN VGMGYLSLLQ VSTFKGWMDI MYAAVDSRAI
EEQPLYETNL YMYLYFVIFI IFGSFFTLNL FIGVIIDNFN QQKSKLGGQD LFMTEEQKKY
YNAMKKLGSK KPQKPIPRPQ NCFQGAIFDF VTKQFFDIAI MGLICLNMVT MMVETDDQST
ETENILFIIN FIFIVIFTGE CTLKMIALRQ YFFSIGWNIF DFIVVILSII GLLLADLIEK
YFVSPTLFRV IRLARIGRVP RLIRGAKGIR TLLFALMMSL PALFNIGLLL FLIIFIFSIF
GMSNFGYVKK EGGIDDMFNF ETLGNSIICL FMITTSAGWD GLLIPMLNSG PPDCDPDVEH
PGTNVR
//
