ID   E5F5P8_METGY            Unreviewed;       313 AA.
AC   E5F5P8;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Putative sinapyl alcohol dehydrogenase {ECO:0000313|EMBL:ADP68558.1};
DE   Flags: Fragment;
OS   Metasequoia glyptostroboides (Dawn redwood) (Sequoia glyptostroboides).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Pinopsida; Pinidae; Conifers II; Cupressales; Cupressaceae;
OC   Metasequoia.
OX   NCBI_TaxID=3371 {ECO:0000313|EMBL:ADP68558.1};
RN   [1] {ECO:0000313|EMBL:ADP68558.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20721545; DOI=10.1007/s00239-010-9378-3;
RA   Guo D.M., Ran J.H., Wang X.Q.;
RT   "Evolution of the Cinnamyl/Sinapyl Alcohol Dehydrogenase (CAD/SAD) gene
RT   family: the emergence of real lignin is associated with the origin of Bona
RT   Fide CAD.";
RL   J. Mol. Evol. 71:202-218(2010).
RN   [2] {ECO:0000313|EMBL:ADP68558.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Guo D.-M., Ran J.-H., Wang X.-Q.;
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; HM185295; ADP68558.1; -; mRNA.
DR   AlphaFoldDB; E5F5P8; -.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR   CDD; cd05283; CAD1; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR047109; CAD-like.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR   PANTHER; PTHR42683:SF85; CINNAMYL ALCOHOL DEHYDROGENASE 6-RELATED; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          1..310
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ADP68558.1"
FT   NON_TER         313
FT                   /evidence="ECO:0000313|EMBL:ADP68558.1"
SQ   SEQUENCE   313 AA;  34160 MW;  483908DA2975453B CRC64;
     VLSPFNFTRR KTGPNDVTFK IAFCGICHSD LHQLRNEWFN SQYPLVPGHE LVGTVTEVGT
     EVKRFAVGDR VGVGCMVRSC HSCDSCEKGL EQYCDKLVFT YNGIDWDGSV TYGGYSSLMV
     CDQKFIIKVP DSLPFDAAAP LLCAGITVYS PMMYFGMTEK GNRLGVVGLG GLGHMAVKFG
     KAFGLHVTVI STSPNKEKEA KEILGADDFL ISKDGNQMKN ATKSLDYIID TVSADHPFPP
     LLNLLKVNGK LVVVGIPDKP LQIPALSVIF GRRLVAGSCI GGIKETQEMM DFCAEHNTTW
     NIETISPVYV TTT
//