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Database: UniProt
Entry: E5KGC8_BRUMA
LinkDB: E5KGC8_BRUMA
Original site: E5KGC8_BRUMA 
ID   E5KGC8_BRUMA            Unreviewed;       419 AA.
AC   E5KGC8;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   13-SEP-2023, entry version 46.
DE   SubName: Full=Putative glutamate-gated chloride channel {ECO:0000313|EMBL:ADR74384.1};
GN   Name=avr-14 {ECO:0000313|EMBL:ADR74384.1};
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279 {ECO:0000313|EMBL:ADR74384.1};
RN   [1] {ECO:0000313|EMBL:ADR74384.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21041637; DOI=10.1073/pnas.1011983107;
RA   Moreno Y., Nabhan J.F., Solomon J., Mackenzie C.D., Geary T.G.;
RT   "Ivermectin disrupts the function of the excretory-secretory apparatus in
RT   microfilariae of Brugia malayi.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:20120-20125(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC       {ECO:0000256|RuleBase:RU000687}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU000687}.
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DR   EMBL; HQ123446; ADR74384.1; -; mRNA.
DR   AlphaFoldDB; E5KGC8; -.
DR   HOGENOM; CLU_010920_1_4_1; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   CDD; cd18993; LGIC_ECD_GluCl; 1.
DR   CDD; cd19062; LGIC_TM_GluCl; 1.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR   Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR044721; GluCl_TM.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   NCBIfam; TIGR00860; LIC; 1.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   PANTHER; PTHR18945:SF923; PROTEIN CBR-AVR-14; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU000687};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU000687};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000687};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU000687};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   CHAIN           19..419
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT                   /id="PRO_5022250620"
FT   TRANSMEM        249..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        314..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   DOMAIN          142..250
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   419 AA;  48680 MW;  ED15CE6F19900055 CRC64;
     MNGCMICWIF TILILVMAKK KLKEQEIIQR TLKDYDWRVR PRGSNLSWPD TGGPVLVSVN
     IYLRSISKID DVNMEYSAQF TFREEWNDAR LAYERLADEN TQVPPFVVLA ASEQADLTQQ
     IWMPDTFFQN EKEARRHLID KPNVLIRIHP DGQILYSVRL SLVLSCPMSL EYYPLDRQTC
     LIDLASYAYT TDDIKYEWKL KNPIQQKEGL RQSLPSFELQ DVLTDYCTSK TNTGEYSCLR
     TKMILRREFS YYLLQLYIPS FMLVIVSWVS FWLDKDSVPA RVTLGVTTLL TMTTQSSGIN
     AKLPPVSYTK AIDVWIGVCL AFIFGALLEF ALVNYAARKD VNAGHRMLSK YANHMDYSSG
     YQPLVSTTAI MTPTRSWWCL RPFVRRYKER SKRIDVVSRL VFPIGYACFN VLYWAVYLI
//
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