ID E5KGC8_BRUMA Unreviewed; 419 AA.
AC E5KGC8;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 13-SEP-2023, entry version 46.
DE SubName: Full=Putative glutamate-gated chloride channel {ECO:0000313|EMBL:ADR74384.1};
GN Name=avr-14 {ECO:0000313|EMBL:ADR74384.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:ADR74384.1};
RN [1] {ECO:0000313|EMBL:ADR74384.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21041637; DOI=10.1073/pnas.1011983107;
RA Moreno Y., Nabhan J.F., Solomon J., Mackenzie C.D., Geary T.G.;
RT "Ivermectin disrupts the function of the excretory-secretory apparatus in
RT microfilariae of Brugia malayi.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:20120-20125(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU000687}.
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DR EMBL; HQ123446; ADR74384.1; -; mRNA.
DR AlphaFoldDB; E5KGC8; -.
DR HOGENOM; CLU_010920_1_4_1; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18993; LGIC_ECD_GluCl; 1.
DR CDD; cd19062; LGIC_TM_GluCl; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR044721; GluCl_TM.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR NCBIfam; TIGR00860; LIC; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR PANTHER; PTHR18945:SF923; PROTEIN CBR-AVR-14; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU000687};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 19..419
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5022250620"
FT TRANSMEM 249..273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 314..337
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 142..250
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 419 AA; 48680 MW; ED15CE6F19900055 CRC64;
MNGCMICWIF TILILVMAKK KLKEQEIIQR TLKDYDWRVR PRGSNLSWPD TGGPVLVSVN
IYLRSISKID DVNMEYSAQF TFREEWNDAR LAYERLADEN TQVPPFVVLA ASEQADLTQQ
IWMPDTFFQN EKEARRHLID KPNVLIRIHP DGQILYSVRL SLVLSCPMSL EYYPLDRQTC
LIDLASYAYT TDDIKYEWKL KNPIQQKEGL RQSLPSFELQ DVLTDYCTSK TNTGEYSCLR
TKMILRREFS YYLLQLYIPS FMLVIVSWVS FWLDKDSVPA RVTLGVTTLL TMTTQSSGIN
AKLPPVSYTK AIDVWIGVCL AFIFGALLEF ALVNYAARKD VNAGHRMLSK YANHMDYSSG
YQPLVSTTAI MTPTRSWWCL RPFVRRYKER SKRIDVVSRL VFPIGYACFN VLYWAVYLI
//