ID E5KV31_AERHY Unreviewed; 473 AA.
AC E5KV31;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Flagellar biosynthesis protein FlhF {ECO:0000256|ARBA:ARBA00014919};
DE AltName: Full=Flagella-associated GTP-binding protein {ECO:0000256|ARBA:ARBA00030866};
DE Flags: Fragment;
GN Name=flhF {ECO:0000313|EMBL:ADQ26729.1};
OS Aeromonas hydrophila.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Aeromonas.
OX NCBI_TaxID=644 {ECO:0000313|EMBL:ADQ26729.1};
RN [1] {ECO:0000313|EMBL:ADQ26729.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AL09-73 {ECO:0000313|EMBL:ADQ26729.1};
RA Yeh H.-Y., Klesius P.H.;
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADQ26729.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AL09-73 {ECO:0000313|EMBL:ADQ26729.1};
RX PubMed=21963857; DOI=10.1016/j.fsi.2011.09.016;
RA Yeh H.Y., Klesius P.H.;
RT "Over-expression, purification and immune responses to Aeromonas hydrophila
RT AL09-73 flagellar proteins.";
RL Fish Shellfish Immunol. 31:1278-1283(2011).
CC -!- FUNCTION: Necessary for flagellar biosynthesis. May be involved in
CC translocation of the flagellum. {ECO:0000256|ARBA:ARBA00025337}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the GTP-binding SRP family.
CC {ECO:0000256|ARBA:ARBA00008531}.
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DR EMBL; HQ216197; ADQ26729.1; -; Genomic_DNA.
DR AlphaFoldDB; E5KV31; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR CDD; cd17873; FlhF; 1.
DR Gene3D; 1.20.120.1380; Flagellar FlhF biosynthesis protein, N domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR020006; FlhF.
DR InterPro; IPR047040; FlhF__GTPase_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000897; SRP54_GTPase_dom.
DR NCBIfam; TIGR03499; FlhF; 1.
DR PANTHER; PTHR43134:SF3; FLAGELLAR BIOSYNTHESIS PROTEIN FLHF; 1.
DR PANTHER; PTHR43134; SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA; 1.
DR Pfam; PF00448; SRP54; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00962; SRP54; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|ARBA:ARBA00022795};
KW Bacterial flagellum protein export {ECO:0000256|ARBA:ARBA00023225};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 253..394
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 254..447
FT /note="SRP54-type proteins GTP-binding"
FT /evidence="ECO:0000259|SMART:SM00962"
FT REGION 51..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADQ26729.1"
SQ SEQUENCE 473 AA; 51833 MW; B8B83D4823755944 CRC64;
VKIKRFFAKD MRTALAEVKE TLGPDAVIMS NKKVTGGVEI VAAVDYQSQV PGPKDAPVRR
QLNDESVNIS SAGRQMTRPA PSPAQEQNEH YADTLAALLA RQQKLNPAQN GQAGQSGAPS
AAASGAPRTL AEQGQWGATP EPAKPKARAA APGRAPQSPQ RDQEMEGMRK EMASIRKLLE
HQISGLMWQE VERREPMRAL LIKELKKIGF DDAFADQLAG LIPEDMSIHQ AMAQLAEVLT
AQLKISEDEI LRQGGAVALL GPTGVGKTTT IAKLAARFAM KYGAEQVALI TTDNYRIGAH
EQLQTYGRIM GCPVRQVRDA EELANALYQF RHRRLVLIDT AGVGQRDIRL TEQLDTLVKN
AKVRIRSYLV MSATSQRRVM QEAVDHFRRI PLSGCILTKL DESLNLGEVI NVCIQNALPI
SYITDGQRVP EDIQVANAAQ LVGAAMGSLE RETEEPYFWG TGFGEAEDSE FYE
//
