ID E5Q7N0_MUSDO Unreviewed; 70 AA.
AC E5Q7N0;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Bone morphogenetic protein {ECO:0000313|EMBL:ADR57144.1};
DE Flags: Fragment;
GN Name=gbb {ECO:0000313|EMBL:ADR57144.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:ADR57144.1};
RN [1] {ECO:0000313|EMBL:ADR57144.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21086136; DOI=10.1007/s00427-010-0341-5;
RA Fritsch C., Lanfear R., Ray R.P.;
RT "Rapid evolution of a novel signalling mechanism by concerted duplication
RT and divergence of a BMP ligand and its extracellular modulators.";
RL Dev. Genes Evol. 0:0-0(2010).
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; HQ592528; ADR57144.1; -; Genomic_DNA.
DR AlphaFoldDB; E5Q7N0; -.
DR VEuPathDB; VectorBase:MDOA011896; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR PANTHER; PTHR11848:SF298; PROTEIN 60A-RELATED; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 1..70
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADR57144.1"
FT NON_TER 70
FT /evidence="ECO:0000313|EMBL:ADR57144.1"
SQ SEQUENCE 70 AA; 7853 MW; 248583BF4A78D4AB CRC64;
DGYGAYYCSG ECNFPLNAHM NATNHAIVQT LVHLLERSKV PKPCCAPTRL GALPVLYHLD
EQHVNLKKYK
//
