ID E5R2B3_ARTGP Unreviewed; 567 AA.
AC E5R2B3;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=NEDD8-activating enzyme E1 regulatory subunit {ECO:0000256|PIRNR:PIRNR039099};
GN ORFNames=MGYG_00046 {ECO:0000313|EMBL:EFQ97003.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.
CC {ECO:0000256|PIRNR:PIRNR039099}.
CC -!- PATHWAY: Protein modification; protein neddylation.
CC {ECO:0000256|ARBA:ARBA00005032, ECO:0000256|PIRNR:PIRNR039099}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. ULA1
CC subfamily. {ECO:0000256|ARBA:ARBA00006868,
CC ECO:0000256|PIRNR:PIRNR039099}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS989822; EFQ97003.1; -; Genomic_DNA.
DR RefSeq; XP_003175955.1; XM_003175907.1.
DR AlphaFoldDB; E5R2B3; -.
DR STRING; 535722.E5R2B3; -.
DR GeneID; 10031266; -.
DR VEuPathDB; FungiDB:MGYG_00046; -.
DR eggNOG; KOG2016; Eukaryota.
DR HOGENOM; CLU_019618_2_1_1; -.
DR InParanoid; E5R2B3; -.
DR OMA; KLITHQY; -.
DR OrthoDB; 5488891at2759; -.
DR UniPathway; UPA00885; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0019781; F:NEDD8 activating enzyme activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045116; P:protein neddylation; IEA:UniProtKB-UniRule.
DR CDD; cd01493; APPBP1_RUB; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR030667; APP-BP1.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR PANTHER; PTHR10953:SF29; NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR Pfam; PF00899; ThiF; 1.
DR PIRSF; PIRSF039099; APP-BP1; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002669};
KW Ubl conjugation pathway {ECO:0000256|PIRNR:PIRNR039099}.
FT DOMAIN 14..565
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
SQ SEQUENCE 567 AA; 62532 MW; 7F59083F27611AB0 CRC64;
MASHAGPTTK ERKYDRQLRL WAASGQQALE SSRVLLINSD GPVDSDGSEL TGVVGVETLK
NLVLPGIGGF TIVDPATVSE LDLGVNFLLS EDSLGKSRAE ETCKYLRELN EDVDGWAYKM
PILDALKDQS FLPQHQLVIV SGPIRQSTLR AISQASRRLD IPLMYTHSVG FYASFSLQLP
SVFPIVETHP DASSTEDLRL TNPWPELAAA AGKAENLDGM DDHQHGHVPY LILLLHFLEQ
WKANHSGQYP QNYQEKSEFR DMVRSKARTN NPEGGEENFD EAVAAVLKSI GPYSLSSDLR
NAFGMEECSQ LTTSSSNFWI ITASVKRFYE THSVLPLSGS LPDMKAQSSD YIWLQNIYKS
KARQDAAEVL ATVRNLECKL RAGLERVPIS EKEVEIFCKN AAHIKVIKGR DIPLLPLDQS
DENSQRIVKA IKSSLEIPDS LIPIFIALST LDSLVAEFKE TGCLNKAEGP SYLDETENWT
AILSKHLAGL GLGENGMDES ESDIKSQIES AVAEVRRAGI GELHNISAMA GGCIAQEALK
VLTRQYVPLD NTFILDGVRS RGEMFRI
//
