ID E5R3F2_ARTGP Unreviewed; 367 AA.
AC E5R3F2;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=NADP-dependent alcohol dehydrogenase 6 {ECO:0000313|EMBL:EFQ97967.1};
GN ORFNames=MGYG_01003 {ECO:0000313|EMBL:EFQ97967.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; DS989822; EFQ97967.1; -; Genomic_DNA.
DR RefSeq; XP_003176919.1; XM_003176871.1.
DR AlphaFoldDB; E5R3F2; -.
DR STRING; 535722.E5R3F2; -.
DR GeneID; 10032241; -.
DR VEuPathDB; FungiDB:MGYG_01003; -.
DR eggNOG; KOG0023; Eukaryota.
DR HOGENOM; CLU_026673_20_2_1; -.
DR InParanoid; E5R3F2; -.
DR OMA; GWGEQKF; -.
DR OrthoDB; 5353053at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF39; NADP-DEPENDENT ALCOHOL DEHYDROGENASE 6-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002669};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 35..150
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 191..316
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 367 AA; 39784 MW; D270D0CBA8EEAEE9 CRC64;
MPSMDEAEGF QVDSAETHTQ FHKRHYKLKP FEDYDVDVKV EACGICGSDI HTITGGWGPK
LFPLCVGHEI VGTAVRVGPK VTLIKEGQRV GIGAQVYSCG TCKQCKNDNE TYCPNVIMDT
YGSKWPGTGI VSQGGYGSHV RVHEHWVFPI PEKLATTSVA PMLCAGITAY SPLVRNGCGP
GKKVGIVGLG GIGHFGVMFA KALGAETWAI SRTRAKEADA RKLGADGFIA TAEEGWEKSH
KFSFDLIINC ANSSKGFALD KYLSLLDVHA KWVSVGLPEE DGPSIKAQSF IANGVLMGAS
HLGSRREMLE MLQLAADKGL QSWVEEIQIG EDGLRDAVTR MKKGDIRYRF TLTGYDTAFS
KPPRPSL
//
