GenomeNet

Database: UniProt
Entry: E5RGT6_HUMAN
LinkDB: E5RGT6_HUMAN
Original site: E5RGT6_HUMAN 
ID   E5RGT6_HUMAN            Unreviewed;       598 AA.
AC   E5RGT6;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   24-JAN-2024, entry version 81.
DE   SubName: Full=FCH and double SH3 domains 1 {ECO:0000313|Ensembl:ENSP00000428677.1};
GN   Name=FCHSD1 {ECO:0000313|Ensembl:ENSP00000428677.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428677.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000428677.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0007829|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [3] {ECO:0000313|Ensembl:ENSP00000428677.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   EMBL; AC008781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC022420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; E5RGT6; -.
DR   SMR; E5RGT6; -.
DR   MassIVE; E5RGT6; -.
DR   MaxQB; E5RGT6; -.
DR   PeptideAtlas; E5RGT6; -.
DR   ProteomicsDB; 15773; -.
DR   Antibodypedia; 27344; 127 antibodies from 26 providers.
DR   Ensembl; ENST00000522783.5; ENSP00000428677.1; ENSG00000197948.11.
DR   UCSC; uc063ick.1; human.
DR   HGNC; HGNC:25463; FCHSD1.
DR   VEuPathDB; HostDB:ENSG00000197948; -.
DR   GeneTree; ENSGT00510000046732; -.
DR   HOGENOM; CLU_013546_0_0_1; -.
DR   ChiTaRS; FCHSD1; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000197948; Expressed in granulocyte and 102 other cell types or tissues.
DR   ExpressionAtlas; E5RGT6; baseline and differential.
DR   CDD; cd07678; F-BAR_FCHSD1; 1.
DR   CDD; cd11895; SH3_FCHSD1_2; 1.
DR   CDD; cd11761; SH3_FCHSD_1; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 2.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR035460; FCHSD_SH3_1.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR15735:SF4; F-BAR AND DOUBLE SH3 DOMAINS PROTEIN 1; 1.
DR   PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF14604; SH3_9; 2.
DR   SMART; SM00055; FCH; 1.
DR   SMART; SM00326; SH3; 2.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 2.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS50002; SH3; 2.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW   Proteomics identification {ECO:0007829|EPD:E5RGT6,
KW   ECO:0007829|MaxQB:E5RGT6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          12..280
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          394..455
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          472..535
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          341..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          535..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        341..365
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        538..569
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   598 AA;  66614 MW;  A5AF8D5030D21750 CRC64;
     MQPPPRKVKP AQEVKLRFLE QLSILQTWQQ READLLEDIR SYSKQRAAIE REYGQALQKL
     AGPFLKREGH RSGEMDSRTV FGAWRCLLDA TVAGGQTRLQ ASDRYRDLAG GTGRSAKEQV
     LRKGTENLQR AQAEVLQSVR ELSRSRKLYG QRERVWALAQ EKAADVQARL NRSDHGIFHS
     RTSLQKLSTK LSAQSAQYSQ QLQAARNEYL LNLVATNAHL DHYYQEELPA LLKALVSELS
     EHLRDPLTSL SHTELEAAEV ILEHAHRGEQ TTSQVSWEQD LKLFLQEPGV FSPTPPQQFQ
     PAGTDQVCVL EWGAEGVAGK SGLEKEVQRL TSRAARDYKI QNHGHRERRL SEARLSQRDL
     SPTAEDAELS DFEECEETGE LFEEPAPQAL ATRALPCPAH VVFRYQAGRE DELTITEGEW
     LEVIEEGDAD EWVKARNQHG EVGFVPERYL NFPDLSLPES SQDSDNPCGA EPTAFLAQAL
     YSYTGQSAEE LSFPEGALIR LLPRAQDGVD DGFWRGEFGG RVGVFPSLLV EELLGPPGPP
     ELSDPEQMLP SPSPPSFSPP APTSVLDGPP APVLPGDSGG TCACLSYGYI AYWWRLGF
//
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