ID E5RGT6_HUMAN Unreviewed; 598 AA.
AC E5RGT6;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 81.
DE SubName: Full=FCH and double SH3 domains 1 {ECO:0000313|Ensembl:ENSP00000428677.1};
GN Name=FCHSD1 {ECO:0000313|Ensembl:ENSP00000428677.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428677.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000428677.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [3] {ECO:0000313|Ensembl:ENSP00000428677.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AC008781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC022420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E5RGT6; -.
DR SMR; E5RGT6; -.
DR MassIVE; E5RGT6; -.
DR MaxQB; E5RGT6; -.
DR PeptideAtlas; E5RGT6; -.
DR ProteomicsDB; 15773; -.
DR Antibodypedia; 27344; 127 antibodies from 26 providers.
DR Ensembl; ENST00000522783.5; ENSP00000428677.1; ENSG00000197948.11.
DR UCSC; uc063ick.1; human.
DR HGNC; HGNC:25463; FCHSD1.
DR VEuPathDB; HostDB:ENSG00000197948; -.
DR GeneTree; ENSGT00510000046732; -.
DR HOGENOM; CLU_013546_0_0_1; -.
DR ChiTaRS; FCHSD1; human.
DR Proteomes; UP000005640; Chromosome 5.
DR Bgee; ENSG00000197948; Expressed in granulocyte and 102 other cell types or tissues.
DR ExpressionAtlas; E5RGT6; baseline and differential.
DR CDD; cd07678; F-BAR_FCHSD1; 1.
DR CDD; cd11895; SH3_FCHSD1_2; 1.
DR CDD; cd11761; SH3_FCHSD_1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR035460; FCHSD_SH3_1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735:SF4; F-BAR AND DOUBLE SH3 DOMAINS PROTEIN 1; 1.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF14604; SH3_9; 2.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 2.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Proteomics identification {ECO:0007829|EPD:E5RGT6,
KW ECO:0007829|MaxQB:E5RGT6};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 12..280
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 394..455
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 472..535
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 341..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..569
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 66614 MW; A5AF8D5030D21750 CRC64;
MQPPPRKVKP AQEVKLRFLE QLSILQTWQQ READLLEDIR SYSKQRAAIE REYGQALQKL
AGPFLKREGH RSGEMDSRTV FGAWRCLLDA TVAGGQTRLQ ASDRYRDLAG GTGRSAKEQV
LRKGTENLQR AQAEVLQSVR ELSRSRKLYG QRERVWALAQ EKAADVQARL NRSDHGIFHS
RTSLQKLSTK LSAQSAQYSQ QLQAARNEYL LNLVATNAHL DHYYQEELPA LLKALVSELS
EHLRDPLTSL SHTELEAAEV ILEHAHRGEQ TTSQVSWEQD LKLFLQEPGV FSPTPPQQFQ
PAGTDQVCVL EWGAEGVAGK SGLEKEVQRL TSRAARDYKI QNHGHRERRL SEARLSQRDL
SPTAEDAELS DFEECEETGE LFEEPAPQAL ATRALPCPAH VVFRYQAGRE DELTITEGEW
LEVIEEGDAD EWVKARNQHG EVGFVPERYL NFPDLSLPES SQDSDNPCGA EPTAFLAQAL
YSYTGQSAEE LSFPEGALIR LLPRAQDGVD DGFWRGEFGG RVGVFPSLLV EELLGPPGPP
ELSDPEQMLP SPSPPSFSPP APTSVLDGPP APVLPGDSGG TCACLSYGYI AYWWRLGF
//