ID E5RIU2_HUMAN Unreviewed; 79 AA.
AC E5RIU2;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=ADP ribosylation factor GTPase activating protein 1 {ECO:0000313|Ensembl:ENSP00000428355.1};
DE Flags: Fragment;
GN Name=ARFGAP1 {ECO:0000313|Ensembl:ENSP00000428355.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000428355.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000428355.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [2] {ECO:0000313|Ensembl:ENSP00000428355.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL121827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E5RIU2; -.
DR SMR; E5RIU2; -.
DR MassIVE; E5RIU2; -.
DR MaxQB; E5RIU2; -.
DR PeptideAtlas; E5RIU2; -.
DR ProteomicsDB; 16395; -.
DR Antibodypedia; 29683; 462 antibodies from 33 providers.
DR Ensembl; ENST00000523114.5; ENSP00000428355.1; ENSG00000101199.13.
DR UCSC; uc061ylc.1; human.
DR HGNC; HGNC:15852; ARFGAP1.
DR VEuPathDB; HostDB:ENSG00000101199; -.
DR GeneTree; ENSGT00890000139515; -.
DR HOGENOM; CLU_023062_4_2_1; -.
DR OMA; MSKLWEV; -.
DR ChiTaRS; ARFGAP1; human.
DR Proteomes; UP000005640; Chromosome 20.
DR Bgee; ENSG00000101199; Expressed in adenohypophysis and 188 other cell types or tissues.
DR ExpressionAtlas; E5RIU2; baseline and differential.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR PANTHER; PTHR46395; ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR46395:SF1; ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Proteomics identification {ECO:0007829|EPD:E5RIU2,
KW ECO:0007829|MaxQB:E5RIU2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 7..79
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT NON_TER 79
FT /evidence="ECO:0000313|Ensembl:ENSP00000428355.1"
SQ SEQUENCE 79 AA; 9029 MW; 2EA0AE48CF3814E1 CRC64;
MASPRTRKVL KEVRVQDENN VCFECGAFNP QWVSVTYGIW ICLECSGRHR GLGVHLSFVR
SVTMDKWKDI ELEKMKAGG
//
