ID E5RX12_BOVIN Unreviewed; 516 AA.
AC E5RX12;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 03-MAY-2023, entry version 42.
DE SubName: Full=Lymphocyte activation gene-3 {ECO:0000313|EMBL:BAJ61118.1};
GN Name=LAG-3 {ECO:0000313|EMBL:BAJ61118.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:BAJ61118.1};
RN [1] {ECO:0000313|EMBL:BAJ61118.1}
RP NUCLEOTIDE SEQUENCE.
RA Shirai T., Konnai S., Ikebuchi R., Okagawa T., Suzuki S., Sunden Y.,
RA Onuma M., Murata S., Ohashi K.;
RT "Molecular cloning of bovine lymphocyte activation gene-3 and its
RT expression characteristics in bovine leukemia virus-infected cattle.";
RL Vet. Immunol. Immunopathol. 144:462-467(2011).
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DR EMBL; AB608100; BAJ61118.1; -; mRNA.
DR RefSeq; NP_001232878.1; NM_001245949.1.
DR AlphaFoldDB; E5RX12; -.
DR GeneID; 515155; -.
DR KEGG; bta:515155; -.
DR CTD; 3902; -.
DR ChiTaRS; LAG3; cattle.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11890:SF18; LYMPHOCYTE ACTIVATION GENE 3 PROTEIN; 1.
DR SMART; SM00409; IG; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..516
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003198712"
FT TRANSMEM 434..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 171..236
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 248..331
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 469..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..503
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 516 AA; 56683 MW; 118DF4E23E71829E CRC64;
MLWEAWFQVW LFLQLLWAAA VEAPEPGAEV PVVWAQEGAP AQLPCSPTIP LQDLSLPRTR
QVTWQHVPES GSAAPTPRGP GPRRYTVLRL APGGLRIGKL PLQPRVQLEE MGLQRGDFSL
WLRPARRADA GEYHAAVRFG NRALACRLRL RVGQAAVTAS PPGPLWTSSW VVLNCSFSRP
DLPASVHWFR GPGRVPVQES PHHHLVGNFL FLPQVSSLDS GTWGCSLTYR DGFNVSITYN
LAVLGLEPRA PLTVYAGAGS KVELPCRLPP GVGIQSSLTA MWTPPGEGPD LLVAGDRNNF
TLRLEAVGQA QAGTYTCRVH LQGRQLSATV TLAVITVTPK PYGSSGSLRK PFCEVTPASG
QERFVWSPLD KRSQRRSPGP WLLTPDARPL SQPWQCHLYQ GERLLGTAVY LTELSHPGAQ
RFGRALGAGR TAHLPLLILG LLFLLLLVTG ASSFHLWRRQ WRPRRFSALE HGTHPSQASS
KTGELEPELE PEPDPEVEPE PEPEPESQPQ LQPEQP
//
