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Database: UniProt
Entry: E5S911_TRISP
LinkDB: E5S911_TRISP
Original site: E5S911_TRISP 
ID   E5S911_TRISP            Unreviewed;       719 AA.
AC   E5S911;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   05-JUL-2017, entry version 27.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=Tsp_00230 {ECO:0000313|EMBL:EFV58693.1};
OS   Trichinella spiralis (Trichina worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6334 {ECO:0000313|EMBL:EFV58693.1, ECO:0000313|Proteomes:UP000006823};
RN   [1] {ECO:0000313|EMBL:EFV58693.1, ECO:0000313|Proteomes:UP000006823}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS 195 {ECO:0000313|EMBL:EFV58693.1,
RC   ECO:0000313|Proteomes:UP000006823};
RX   PubMed=21336279; DOI=10.1038/ng.769;
RA   Mitreva M., Jasmer D.P., Zarlenga D.S., Wang Z., Abubucker S.,
RA   Martin J., Taylor C.M., Yin Y., Fulton L., Minx P., Yang S.P.,
RA   Warren W.C., Fulton R.S., Bhonagiri V., Zhang X., Hallsworth-Pepin K.,
RA   Clifton S.W., McCarter J.P., Appleton J., Mardis E.R., Wilson R.K.;
RT   "The draft genome of the parasitic nematode Trichinella spiralis.";
RL   Nat. Genet. 43:228-235(2011).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFV58693.1}.
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DR   EMBL; ABIR02000721; EFV58693.1; -; Genomic_DNA.
DR   RefSeq; XP_003376062.1; XM_003376014.1.
DR   EnsemblMetazoa; EFV58693; EFV58693; EFV58693.
DR   GeneID; 10901537; -.
DR   KEGG; tsp:Tsp_00230; -.
DR   CTD; 10901537; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; E5S911; -.
DR   KO; K02154; -.
DR   OMA; LGTQNFG; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000006823; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006823};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006823};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    273    297       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    318    336       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    406    426       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    438    459       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    522    541       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    648    672       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   719 AA;  81497 MW;  D0B5F8F98DC6EE07 CRC64;
     MQSLHANDGS LGQVNPALEY DGELIVTGDH KESFGGKLNL DFVVGVILRE RIPAFERLLW
     RACRGNVFLK QAEITESLED PATGDLVQKS VILIFFQGEQ LKSRVKKICE GFRATLYPCP
     ETPQERREMA IGVMTRIEDL KTVLGQTQDH RHRVLVAAAK NIRIWFTKVR KIKSIYHTLN
     LFNLDVTQKC LIAECWCPVA DLDKIQLALK RGTEESGSSV PSILNRMYTT EAPPTYNRTN
     KFTAGFQNIV DAYGVASYRE VNPALYTIIT FPFLFAIMFG DFGHGLIMFL FALFLIVKEK
     QLIARKIRDE VFNIFFGGRY IIFLMGLFSM YTGIVYNEVY AKSVNIFGSS WVIPPEVDDN
     VLANMEKIQL NPNTSFLGHA YAYGIDPAWN IAVNKLNFLN SFKMKMSVII GVFQMIFGVV
     LSLFNYRFFN RKLDIYTMFI PQMLFMCCIF LYLCMLIIYK WTAFSAAPAD MAVGHYPGSH
     CAPSLLIGLI FMFMFQQRNY GFADSKCVTN AFYPGQVGFE QFLVVVAVLC APTMLFVKPY
     LIYRERKNRL NDGHIAIHAD MNSDDAEAVQ IKQKASSSTS AGAHDEHDDM NIGEIFIIQA
     IHTIEFCLGC ISHTASYLRL WALSLAHAQL SEVLWSMVLR IAFGFQGYAG AIAVYLIVWA
     FGMLTICILV LMEGLSAFLH ALRLHWVEFQ SKFYTGSGYL FTPFSFDVIL EQARIEDGD
//
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