ID E5VKC7_9FIRM Unreviewed; 655 AA.
AC E5VKC7;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=HMPREF0996_01488 {ECO:0000313|EMBL:EFV16742.1};
OS Lachnospiraceae bacterium 5_1_63FAA.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=658089 {ECO:0000313|EMBL:EFV16742.1, ECO:0000313|Proteomes:UP000005278};
RN [1] {ECO:0000313|EMBL:EFV16742.1, ECO:0000313|Proteomes:UP000005278}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5_1_63FAA {ECO:0000313|EMBL:EFV16742.1,
RC ECO:0000313|Proteomes:UP000005278};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Earl A., Feldgarden M., Young S.K., Gargeya S., Zeng Q.,
RA Alvarado L., Berlin A., Bochicchio J., Chapman S.B., Chen Z., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., White J., Yandava C.,
RA Allen-Vercoe E., Ambrose C., Strauss J., Daigneault M., Haas B.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium strain 5_1_63FAA.";
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFV16742.1}.
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DR EMBL; ACTS01000033; EFV16742.1; -; Genomic_DNA.
DR AlphaFoldDB; E5VKC7; -.
DR HOGENOM; CLU_004585_5_5_9; -.
DR Proteomes; UP000005278; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW ECO:0000313|EMBL:EFV16742.1};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 34..321
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 322..589
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 55..62
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 655 AA; 76304 MW; 150CAAB0A34C74F7 CRC64;
MTFDRALSFC CHFVIIGLIE HIYGRNFILD QLLCQLNQAQ LEAVTSTEGF IRVIAGAGSG
KTRALSHRFA FLVNEIGILP GNILCVTFTN KAANEMRHRI HNLIADNDTG YINTFHGFCV
SILQEDSHAI QYPKNFLVLD NQDIDSMLKI IYEERGLTLR HKTFSKARDM IEMYKLERYP
NYYLDLITMS LDTLRQKYLG ATDVNDIIFY GYLYQEKKCF GLDYNDLLKF SLYIFEKNKE
IRLKWQKRLE YIMIDEFQDI DKIQYQLMKV LCGYHKNLFI VGDPDQTIYS WRGADINYLL
NFDKAFPDVK TIMMNENYRS TPQILSVCNS LIDKNKNRMK KDLLPMCHSK NSVLYYHGDT
SEEESDWIAD QIIKLHKKDI SYKDITILYR AHYVTRTLEE TLLKKKIPYS IYSGIQFFER
MEVKDALSYL RMITYKDDLS FLRIVNVPKR NIGKKRMEFL QAYVNAHHCS FYEALKECVE
DPIFKGTDAK DFISLIDAFS VTYEQRTISE VLSDILDRSG YEEMLRTTGN QERLDNLAEL
KQAVYDYEIS CGEEALLPDY LDHIALFTNS DVTDDSDKVK LMTVHAAKGL EFPHVFLCAL
NEGIFPSKKT STIEGMEEER RLAFVAMSRA MKSLFLSESH GKILMDQPVT HLDLF
//