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Database: UniProt
Entry: E5Y7Z5_BILWA
LinkDB: E5Y7Z5_BILWA
Original site: E5Y7Z5_BILWA 
ID   E5Y7Z5_BILWA            Unreviewed;       522 AA.
AC   E5Y7Z5;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 2.
DT   25-OCT-2017, entry version 45.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   ORFNames=HMPREF0179_02310 {ECO:0000313|EMBL:EFV43870.2};
OS   Bilophila wadsworthia 3_1_6.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Bilophila.
OX   NCBI_TaxID=563192 {ECO:0000313|EMBL:EFV43870.2, ECO:0000313|Proteomes:UP000006034};
RN   [1] {ECO:0000313|EMBL:EFV43870.2, ECO:0000313|Proteomes:UP000006034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3_1_6 {ECO:0000313|EMBL:EFV43870.2,
RC   ECO:0000313|Proteomes:UP000006034};
RG   The Broad Institute Genome Sequencing Platform;
RA   Ward D., Earl A., Feldgarden M., Young S.K., Gargeya S., Zeng Q.,
RA   Alvarado L., Berlin A., Bochicchio J., Chapman S.B., Chen Z.,
RA   Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heilman E., Heiman D., Howarth C., Mehta T., Neiman D., Pearson M.,
RA   Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA   White J., Yandava C., Allen-Vercoe E., Sibley C., Ambrose C.E.,
RA   Strauss J., Daigneault M., Haas B., Nusbaum C., Birren B.;
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EFV43870.2, ECO:0000313|Proteomes:UP000006034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3_1_6 {ECO:0000313|EMBL:EFV43870.2,
RC   ECO:0000313|Proteomes:UP000006034};
RG   The Broad Institute Genomics Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Sibley C., Strauss J.,
RA   Allen-Vercoe E., Walker B., Young S., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Bilophila wadsworthia 3_1_6.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFV43870.2}.
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DR   EMBL; ADCP02000001; EFV43870.2; -; Genomic_DNA.
DR   RefSeq; WP_016360649.1; NZ_KE150238.1.
DR   STRING; 563192.HMPREF0179_02310; -.
DR   EnsemblBacteria; EFV43870; EFV43870; HMPREF0179_02310.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000006034; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR002611; IstB_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 2.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF01695; IstB_IS21; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006034};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006034}.
FT   DOMAIN      201    351       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      427    496       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   522 AA;  57892 MW;  DBCD193EE3C32EE9 CRC64;
     MELRNAVSKE TLRKYLLTSS AEAIPQARPS LLSCFTNAEN PKPQLQDRLS AAGEALESCS
     ETALQSWFDP LEILLDQEAG TLAVRFPHAF FGIRFSSLFQ KLFEKKAREL WGKGLSITYG
     AGKFTPSPPV PFVQPAPESR QDALHPAVAN PMPFGEEWTF DTFIGNGKHK WALSLARDIT
     RRAVYRATHG RAPSLDDIGE APGLLVLCGP HGTGKTHLLR AIGNELFRTL GSDLYYASLS
     DLELLFAGRS VLAARQELLS KEAVLIDDFQ HLSRIPDKTP TTASRFRAQI VAEPEQPAGP
     SVREELCLLL DRFMDQGKPV IVAGVGRPKE WSLGKALLSR LETGLWAELP EPDLDVRLRY
     AQQQAKFRRL PLSREQLLLI AQHCPDVRRL SGVILRVASH RSLLGRDLSE QDLLNIVRQG
     GDSSALTPQL IVSIVGEHCG VPAKEILGEK RRPDLVQARQ LAMYLCRELL GHSYPVIGRM
     FGGKDHSTVM HGVKKIKLLQ ESDRLAHSMV TELTKACLEH RG
//
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