ID E6J1J6_STRAP Unreviewed; 299 AA.
AC E6J1J6;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=UTP--glucose-1-phosphate uridylyltransferase {ECO:0000256|ARBA:ARBA00012415, ECO:0000256|RuleBase:RU361259};
DE EC=2.7.7.9 {ECO:0000256|ARBA:ARBA00012415, ECO:0000256|RuleBase:RU361259};
DE AltName: Full=UDP-glucose pyrophosphorylase {ECO:0000256|RuleBase:RU361259};
GN Name=galU {ECO:0000313|EMBL:EFU22225.1};
GN ORFNames=HMPREF0813_01121 {ECO:0000313|EMBL:EFU22225.1};
OS Streptococcus anginosus F0211.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus; Streptococcus anginosus group.
OX NCBI_TaxID=706437 {ECO:0000313|EMBL:EFU22225.1, ECO:0000313|Proteomes:UP000002973};
RN [1] {ECO:0000313|EMBL:EFU22225.1, ECO:0000313|Proteomes:UP000002973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0211 {ECO:0000313|EMBL:EFU22225.1,
RC ECO:0000313|Proteomes:UP000002973};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC ChEBI:CHEBI:58885; EC=2.7.7.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000872,
CC ECO:0000256|RuleBase:RU361259};
CC -!- PATHWAY: Carbohydrate metabolism; nucleotide-sugar metabolism.
CC {ECO:0000256|ARBA:ARBA00005136}.
CC -!- SIMILARITY: Belongs to the UDPGP type 2 family.
CC {ECO:0000256|ARBA:ARBA00006890, ECO:0000256|RuleBase:RU361259}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFU22225.1}.
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DR EMBL; AECT01000019; EFU22225.1; -; Genomic_DNA.
DR RefSeq; WP_003028634.1; NZ_AECT01000019.1.
DR AlphaFoldDB; E6J1J6; -.
DR eggNOG; COG1210; Bacteria.
DR UniPathway; UPA00215; -.
DR Proteomes; UP000002973; Unassembled WGS sequence.
DR GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR CDD; cd02541; UGPase_prokaryotic; 1.
DR InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR NCBIfam; TIGR01099; galU; 1.
DR PANTHER; PTHR43197; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR43197:SF1; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU361259,
KW ECO:0000313|EMBL:EFU22225.1};
KW Transferase {ECO:0000256|RuleBase:RU361259, ECO:0000313|EMBL:EFU22225.1}.
FT DOMAIN 6..267
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 299 AA; 33227 MW; 487AEFE0095BE2EE CRC64;
MTQVRKAVIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI KDILVVTGKS
KRSIEDHFDS NFELEYNLKE KGKSDLLKLV DETTGIGLHF IRQSHPRGLG DAVLQAKAFV
GNEPFVVMLG DDLMDITNDK AVPLTKQLMN DYEETHASTI AVMKVPHDEV SSYGVIDPQG
EGVNGLYSVE TFVEKPKPED APSDLAIIGR YLLTPEIFSI LETQKPGAGN EIQLTDAIDT
LNKTQRVFAR EFTGDRYDVG DKFGFMKTSI DYALKHPQVK DDMKQYIIEL GKKLDKKEN
//
