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Database: UniProt
Entry: E6K090_PARDN
LinkDB: E6K090_PARDN
Original site: E6K090_PARDN 
ID   E6K090_PARDN            Unreviewed;       286 AA.
AC   E6K090;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   24-JAN-2024, entry version 58.
DE   SubName: Full=Oxidoreductase, aldo/keto reductase family protein {ECO:0000313|EMBL:EFT83281.1};
GN   ORFNames=HMPREF0620_0286 {ECO:0000313|EMBL:EFT83281.1};
OS   Parascardovia denticolens DSM 10105 = JCM 12538.
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Parascardovia.
OX   NCBI_TaxID=864564 {ECO:0000313|EMBL:EFT83281.1, ECO:0000313|Proteomes:UP000004946};
RN   [1] {ECO:0000313|EMBL:EFT83281.1, ECO:0000313|Proteomes:UP000004946}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10105 {ECO:0000313|EMBL:EFT83281.1,
RC   ECO:0000313|Proteomes:UP000004946};
RA   Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA   Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA   Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA   Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA   Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA   Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA   Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA   Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA   Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA   Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA   Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA   Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA   Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA   Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA   Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFT83281.1}.
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DR   EMBL; AEON01000001; EFT83281.1; -; Genomic_DNA.
DR   AlphaFoldDB; E6K090; -.
DR   KEGG; pdo:PSDT_1299; -.
DR   PATRIC; fig|864564.6.peg.1426; -.
DR   eggNOG; COG0656; Bacteria.
DR   HOGENOM; CLU_023205_0_3_11; -.
DR   Proteomes; UP000004946; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd19133; AKR_AKR5F1; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR   PANTHER; PTHR43827:SF3; ALDO_KET_RED DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000004946}.
FT   DOMAIN          26..259
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        50
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         108
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            75
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   286 AA;  32389 MW;  CAB90E425D25626A CRC64;
     MVPSVTLNNG ISMPQEGFGV FQIPRHDECK QAVTDALEVG YRLIDTAQFY RNERAVGEAL
     EESGLPRREI FLTTKVWINN FGYDKTIESV KRSLRLLRTD YLDLVLIHQA VGNYLWAYRA
     LEDLYKDGLV KAIGVSNMEA DRLIDLATRA NVVPAVNQIE NHVFFQQNDL LAVMKDHGIQ
     GEAWGPFAEG KNDLFTHPLL TEIGTAYDKS AAQVALRFLA QRGLVVIPKS THRDRMEQNL
     DIWDFALSED DMDRISSLDT GKSLFGYAKM FSNIQRLGLF TAKKKD
//
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