ID E6K0E1_PARDN Unreviewed; 493 AA.
AC E6K0E1;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Lyase {ECO:0000313|EMBL:EFT84214.1};
GN ORFNames=HMPREF0620_1219 {ECO:0000313|EMBL:EFT84214.1};
OS Parascardovia denticolens DSM 10105 = JCM 12538.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Parascardovia.
OX NCBI_TaxID=864564 {ECO:0000313|EMBL:EFT84214.1, ECO:0000313|Proteomes:UP000004946};
RN [1] {ECO:0000313|EMBL:EFT84214.1, ECO:0000313|Proteomes:UP000004946}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10105 {ECO:0000313|EMBL:EFT84214.1,
RC ECO:0000313|Proteomes:UP000004946};
RA Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes two reactions in de novo purine nucleotide
CC biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-
CC succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-
CC D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-
CC carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-
CC ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate
CC (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP)
CC and fumarate. {ECO:0000256|ARBA:ARBA00025012}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFT84214.1}.
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DR EMBL; AEON01000001; EFT84214.1; -; Genomic_DNA.
DR RefSeq; WP_006289818.1; NZ_CM001148.1.
DR AlphaFoldDB; E6K0E1; -.
DR KEGG; pdo:PSDT_0450; -.
DR PATRIC; fig|864564.6.peg.494; -.
DR eggNOG; COG0015; Bacteria.
DR HOGENOM; CLU_025566_2_0_11; -.
DR Proteomes; UP000004946; Chromosome.
DR GO; GO:0004018; F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; IEA:InterPro.
DR GO; GO:0006188; P:IMP biosynthetic process; IEA:InterPro.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR InterPro; IPR047136; PurB_bact.
DR InterPro; IPR013539; PurB_C.
DR PANTHER; PTHR43411; ADENYLOSUCCINATE LYASE; 1.
DR PANTHER; PTHR43411:SF1; ADENYLOSUCCINATE LYASE; 1.
DR Pfam; PF08328; ASL_C; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:EFT84214.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004946}.
FT DOMAIN 17..328
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 350..469
FT /note="Adenylosuccinate lyase PurB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08328"
SQ SEQUENCE 493 AA; 54590 MW; 403F1432E48DADBC CRC64;
MELAEITPGL ALSPLDGRYQ AQTLPLVEYL SEAALNRERM VVEVEWMIHL ANGSHDADAD
SRIPGVSPLT AEEIAYLHAI PEDFGAEGIE ELAEIEAVTH HDVKAVEYYI DRRLDAAAQS
LGESSQLPRL KPLVHFSCTS EDINNLSYAL CLKQAVEKVW HPRIQELLDK LDSASQKFAS
TPLLSLTHGQ PATPTTLGKE LAVYVYRLNR QLAKVDGQEY LGKINGATGT FGAHSVALPQ
VDWISVSRSF VEDRLHLTWN PLTTQIESHD WQAELYSTMS HINHILHNLA VDIWMYISRG
VFAQVPVKGA TGSSTMPHKV NPIRFENAEA NLELSCALFD SLSATLVETR WQRDLTDSTA
QRNIGTAFGY NLLALYNLTG GLDSIHPDES TMEAELESNW EVLGEPIQTA MRAAALEGRE
GMGNPYERVK ELMRGKRINQ ADVESFIATL NFDPETSQRL AALTPRTYVG LAADLVAFRE
VRGKESQSTK AGQ
//
