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Database: UniProt
Entry: E6K5A5_9BACT
LinkDB: E6K5A5_9BACT
Original site: E6K5A5_9BACT 
ID   E6K5A5_9BACT            Unreviewed;       324 AA.
AC   E6K5A5;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   07-JUN-2017, entry version 33.
DE   RecName: Full=Lipoate--protein ligase {ECO:0000256|SAAS:SAAS00603724};
DE            EC=6.3.1.20 {ECO:0000256|SAAS:SAAS00603724};
GN   Name=lipA {ECO:0000313|EMBL:EFU31238.1};
GN   ORFNames=HMPREF6485_0954 {ECO:0000313|EMBL:EFU31238.1};
OS   Prevotella buccae ATCC 33574.
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=873513 {ECO:0000313|EMBL:EFU31238.1, ECO:0000313|Proteomes:UP000003112};
RN   [1] {ECO:0000313|EMBL:EFU31238.1, ECO:0000313|Proteomes:UP000003112}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33574 {ECO:0000313|EMBL:EFU31238.1,
RC   ECO:0000313|Proteomes:UP000003112};
RA   Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z.,
RA   Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA   Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L.,
RA   Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D.,
RA   Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R.,
RA   San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S.,
RA   Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K.,
RA   Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA   Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA   Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA   Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA   Petrosino J., Highlander S., Gibbs R.;
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + (R)-lipoate + a [lipoyl-carrier
CC       protein]-L-lysine = a [lipoyl-carrier protein]-N(6)-(lipoyl)lysine
CC       + AMP + diphosphate. {ECO:0000256|SAAS:SAAS00603726}.
CC   -!- PATHWAY: Protein modification; protein lipoylation via exogenous
CC       pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.
CC       {ECO:0000256|SAAS:SAAS00701662}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFU31238.1}.
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DR   EMBL; AEPD01000017; EFU31238.1; -; Genomic_DNA.
DR   RefSeq; WP_004344906.1; NZ_GL586311.1.
DR   EnsemblBacteria; EFU31238; EFU31238; HMPREF6485_0954.
DR   OrthoDB; POG091H03KP; -.
DR   UniPathway; UPA00537; UER00595.
DR   Proteomes; UP000003112; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009249; P:protein lipoylation; IEA:InterPro.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   InterPro; IPR019491; Lipoate_protein_ligase_C.
DR   InterPro; IPR004562; LipoylTrfase_LipoateP_Ligase.
DR   PANTHER; PTHR12561; PTHR12561; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   Pfam; PF10437; Lip_prot_lig_C; 1.
DR   TIGRFAMs; TIGR00545; lipoyltrans; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00428641};
KW   Complete proteome {ECO:0000313|Proteomes:UP000003112};
KW   Ligase {ECO:0000256|SAAS:SAAS00603725, ECO:0000313|EMBL:EFU31238.1};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00026749};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003112};
KW   Transferase {ECO:0000313|EMBL:EFU31238.1}.
FT   DOMAIN       28    212       BPL/LPL catalytic. {ECO:0000259|PROSITE:
FT                                PS51733}.
SQ   SEQUENCE   324 AA;  37470 MW;  2C3071EA7B32CF57 CRC64;
     MKYVALPEEK VRRLSFYLAM EEYVARHVDE DDSFFMWQVE PSVIFGRNQL IENEVNLDYC
     RANHIATFRR KSGGGCVYAD MKNIMFSYIT KEDNVSLTFS RYINMVVEVL HRLGVDARAS
     GRNDIMIGDR KVSGSAFYHL PGRSIVHSTM LYDTDMRNMV GAITPTDEKL ISKGVQSVRQ
     HIALLKDHLS LSIDEFKDFV RHNLCDGETV LTETDVTGIE DIEREYLSQK FIYGNNPKYT
     VVKRHRLEGV GEFEVRMELH NNIVKDINLM GDYFITGDMD GQLLRPLRGL RLEREALEQV
     LPERLDEVVM NLRRDDFIGL LLCP
//
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