ID E6MGK8_9FIRM Unreviewed; 582 AA.
AC E6MGK8;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=DNA (Cytosine-5-)-methyltransferase {ECO:0000313|EMBL:EFV01748.1};
GN ORFNames=HMP0721_1141 {ECO:0000313|EMBL:EFV01748.1};
OS Pseudoramibacter alactolyticus ATCC 23263.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Pseudoramibacter.
OX NCBI_TaxID=887929 {ECO:0000313|EMBL:EFV01748.1, ECO:0000313|Proteomes:UP000004754};
RN [1] {ECO:0000313|EMBL:EFV01748.1, ECO:0000313|Proteomes:UP000004754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23263 {ECO:0000313|EMBL:EFV01748.1,
RC ECO:0000313|Proteomes:UP000004754};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFV01748.1}.
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DR EMBL; AEQN01000016; EFV01748.1; -; Genomic_DNA.
DR RefSeq; WP_006598565.1; NZ_GL622359.1.
DR AlphaFoldDB; E6MGK8; -.
DR STRING; 887929.HMP0721_1141; -.
DR eggNOG; COG2189; Bacteria.
DR HOGENOM; CLU_029607_1_0_9; -.
DR OrthoDB; 9800801at2; -.
DR Proteomes; UP000004754; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR002295; N4/N6-MTase_EcoPI_Mod-like.
DR InterPro; IPR001091; RM_Methyltransferase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR022221; TypeIII_RM_meth.
DR PANTHER; PTHR13370:SF32; DNA ADENINE METHYLTRANSFERASE YHDJ; 1.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR Pfam; PF12564; TypeIII_RM_meth; 1.
DR PIRSF; PIRSF015855; TypeIII_Mtase_mKpnI; 2.
DR PRINTS; PR00508; S21N4MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EFV01748.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004754};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EFV01748.1}.
FT DOMAIN 39..94
FT /note="Type III restriction/modification enzyme methylation
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF12564"
FT DOMAIN 196..451
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
SQ SEQUENCE 582 AA; 67011 MW; 8059ABEBB0510695 CRC64;
MNKNIFEIVV GVLKTNSKYI SDDGKLLKAM VYSDVMTMNK ELLSLLLSDE KIKERFFENV
NGTLVFDKQK FAWFIESKEF LPDSYTRYTN KIGLTHNGDF ISKSNDVVLD FPYKDCVLEG
GQDKDDQKRN EIFYNETIAS DEISKMLAPK VFTNAKRYSK DGIEENITFD EKDNLIIKGN
NLIALSSLLK RYEGKVKCVY IDPPFNTGSD SFNYNDKFSR STWLVFMKNR LELAKRLLHV
TGNIFVHIDI NQSHYLKTLC DGIFGEDNFV EEIIWAYGSP SGGRAATPKP VNIHDYILHY
AKSYSERKQN RVYVPYSEKY IKDWFKYIDD DGRKYRRRQR GKDENGNPIW TKQYLDESKG
VPLSTVWNDI QQVYADPRAY KDGNKTDVEV LKEFKGGQKP EALIKRILEM ATDEGDLVLD
FHIGTGTSAA TAHKLNRKYI GVEQMVNQID LILPRLQKVI GGDTAGISKF VEWKGGGSFV
YCELLENAST LIEKIQSASE ETISEIKSEI YTDERIIPYI TRIELEKADE EFNSLELEEK
KKALISLVDK NKLYVNYSDI DDESYAINES DKAFTKSFYA EV
//
