ID E6MME4_9BACT Unreviewed; 556 AA.
AC E6MME4;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=AMP-binding enzyme {ECO:0000313|EMBL:EFV05198.1};
GN ORFNames=HMPREF9420_0662 {ECO:0000313|EMBL:EFV05198.1};
OS Segatella salivae DSM 15606.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Segatella.
OX NCBI_TaxID=888832 {ECO:0000313|EMBL:EFV05198.1, ECO:0000313|Proteomes:UP000003874};
RN [1] {ECO:0000313|EMBL:EFV05198.1, ECO:0000313|Proteomes:UP000003874}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15606 {ECO:0000313|EMBL:EFV05198.1,
RC ECO:0000313|Proteomes:UP000003874};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-
CC CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560,
CC ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024484};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422;
CC Evidence={ECO:0000256|ARBA:ARBA00024484};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFV05198.1}.
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DR EMBL; AEQO01000072; EFV05198.1; -; Genomic_DNA.
DR RefSeq; WP_007133939.1; NZ_GL629647.1.
DR AlphaFoldDB; E6MME4; -.
DR STRING; 888832.HMPREF9420_0662; -.
DR eggNOG; COG1022; Bacteria.
DR HOGENOM; CLU_000022_59_9_10; -.
DR OrthoDB; 9778383at2; -.
DR Proteomes; UP000003874; Unassembled WGS sequence.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43272:SF83; ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J; 1.
DR PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000003874}.
FT DOMAIN 19..411
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 556 AA; 63308 MW; B3DCB886496E93E2 CRC64;
MDSQPNFNRF IEQSIINNWD KDALTDYKGA TLQFHDVARK IEKLHILFEN SGLHKGDKIA
ICGRNSSHWA VAFLATLTYG AVAVPIQNEF KPEQIHNIVN HSESRFLFVG DVVAKEIDAE
EMPSLEGILY LPDFSIVLSR SEKFTFAREY LNEIFGKRYP KYFRQEHIHY HQDQPEELAL
INYTSGTTGF SKGVMLPYRA LTGNYLFLEE VIGSKIPKHC NVLAILTMAH MYGMMCELIL
EFCLGNHTYF LTRLPSPTLI QQAFAEIHPA MIFSVPLVVE KIIRKNVFPK IQSNIYKLLM
TMPVINKKVK QRILDIVQAE FGGAMYQVAV GGAGLNKEIE DFLINIGFPI TMVYGTTETA
PLITYVDWHD FIPRSCGKPV KFMDVKITSN DPETVPGEII TQGQNVMLGY YKNQEATDAV
IDKNGWFHTG DLATMSKDGH IFIRGRIKNM LLGANGQNVF PEEIENKLNS MTLVNESLVI
QKGEKIIALV HPDYEEVESL NFSEDDLKQV MEQNRNELNA ILPKYASLSA IQIQKEEFAK
TPKKSIKRYL YQNTIQ
//
