ID E6MQI0_9BACT Unreviewed; 359 AA.
AC E6MQI0;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Efflux transporter, RND family, MFP subunit {ECO:0000313|EMBL:EFV04094.1};
GN Name=mexA {ECO:0000313|EMBL:EFV04094.1};
GN ORFNames=HMPREF9420_1748 {ECO:0000313|EMBL:EFV04094.1};
OS Segatella salivae DSM 15606.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Segatella.
OX NCBI_TaxID=888832 {ECO:0000313|EMBL:EFV04094.1, ECO:0000313|Proteomes:UP000003874};
RN [1] {ECO:0000313|EMBL:EFV04094.1, ECO:0000313|Proteomes:UP000003874}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15606 {ECO:0000313|EMBL:EFV04094.1,
RC ECO:0000313|Proteomes:UP000003874};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFV04094.1}.
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DR EMBL; AEQO01000145; EFV04094.1; -; Genomic_DNA.
DR RefSeq; WP_007135007.1; NZ_GL629647.1.
DR AlphaFoldDB; E6MQI0; -.
DR STRING; 888832.HMPREF9420_1748; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_2_1_10; -.
DR OrthoDB; 9801814at2; -.
DR Proteomes; UP000003874; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF23; MULTIDRUG RESISTANCE PROTEIN MEXA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000003874}.
FT DOMAIN 51..259
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 89..116
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 359 AA; 39560 MW; ACBEBE12DCD0EA43 CRC64;
MKKEMLLMAI ITLIVVTGCR KNKENSDQTV YAVTSPWVTN TQVSKDYVAN IESRKNIEVR
AQQEGILQQV YVTEGQQVRA GQPLFRISIV GAQQNVARAK AEAEQARIEL QNTTTLTRGQ
IVSPNAQKMA KAKLNAALAD YKLAQIQARL CLISAPFTGV IGSLPKKIGS LVQGGDLLTT
LSDNSSLNVY FNISEPEYID YQQHSAERNK LPLTLILANG SAFSAKGYIQ NIAGEFDSSS
GNIALRAHFA NPKGLLRNGE TGTVRINMPL HNVLVIPQQA TYEEEDRRYV FVVDGAGYAH
SREIKVAFEQ PEVFIIAEGL TANDKILLSG VQKVHDGQHV KTRYYTPSKA MKRVQLNAD
//
