ID E6NQH5_HELPQ Unreviewed; 856 AA.
AC E6NQH5;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Chaperone protein ClpB {ECO:0000256|ARBA:ARBA00017574};
GN Name=clpB {ECO:0000313|EMBL:BAJ59391.1};
GN OrderedLocusNames=HPF57_0317 {ECO:0000313|EMBL:BAJ59391.1};
OS Helicobacter pylori (strain F57).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=866346 {ECO:0000313|EMBL:BAJ59391.1, ECO:0000313|Proteomes:UP000008082};
RN [1] {ECO:0000313|EMBL:BAJ59391.1, ECO:0000313|Proteomes:UP000008082}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F57 {ECO:0000313|EMBL:BAJ59391.1,
RC ECO:0000313|Proteomes:UP000008082};
RX PubMed=21575176; DOI=10.1186/1471-2180-11-104;
RA Kawai M., Furuta Y., Yahara K., Tsuru T., Oshima K., Handa N.,
RA Takahashi N., Yoshida M., Azuma T., Hattori M., Uchiyama I., Kobayashi I.;
RT "Evolution in an oncogenic bacterial species with extreme genome
RT plasticity: Helicobacter pylori East Asian genomes.";
RL BMC Microbiol. 11:104-104(2011).
RN [2] {ECO:0000313|EMBL:BAJ59391.1, ECO:0000313|Proteomes:UP000008082}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F57 {ECO:0000313|EMBL:BAJ59391.1,
RC ECO:0000313|Proteomes:UP000008082};
RX PubMed=21212362; DOI=10.1073/pnas.1012579108;
RA Furuta Y., Kawai M., Yahara K., Takahashi N., Handa N., Tsuru T.,
RA Oshima K., Yoshida M., Azuma T., Hattori M., Uchiyama I., Kobayashi I.;
RT "Birth and death of genes linked to chromosomal inversion.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:1501-1506(2011).
CC -!- SUBUNIT: Homohexamer. The oligomerization is ATP-dependent.
CC {ECO:0000256|ARBA:ARBA00026057}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
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DR EMBL; AP011945; BAJ59391.1; -; Genomic_DNA.
DR RefSeq; WP_001048014.1; NC_017367.1.
DR AlphaFoldDB; E6NQH5; -.
DR KEGG; hex:HPF57_0317; -.
DR PATRIC; fig|866346.4.peg.342; -.
DR HOGENOM; CLU_005070_4_0_7; -.
DR Proteomes; UP000008082; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 78, MITOCHONDRIAL; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:BAJ59391.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:BAJ59391.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 4..144
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT COILED 409..489
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 856 AA; 96551 MW; 361FA2A33E729369 CRC64;
MNLFEKMTDQ LHETLDSALA LALHHKNAEV TPLHMLFVML NNSQGILIQA LQKMSVDIQA
LRLSVQSELN KLAKVSQINK QNIQLNQALI QSLENAQGLM AKIGDSFIAT DVYLLANMSL
FESVLKPYLD TKELQKTLEA LRKGATIQGK NDDSNWESLE KFGIDLTQKA LENKLDPVIG
RDEEIIRMMQ ILIRKTKNNP ILLGEPGVGK TAVVEGLAQR IVNKEVPKTL LNKRVVALDL
SLLVAGAKYR GEFEERLKKV IEEVKKSANV ILFIDEIHTI VGAGASEGGM DAANILKPAL
ARGELHTIGA TTLKEYRKYF EKDMALQRRF QPILLNEPSI NEALQILRGL KETLETHHNI
TINDSALIAS AKLSSRYITD RFLPDKAIDL IDEGAAQLKM QMESEPAKLS SVKRSIQRLE
MERQALEMEK KESNAKRMQE ILKELSDLKE EKIQLEAQFE NEKEVFREIS RLKMETESLK
KEAERFKRNG DYQQAGEIEY SKIPENKKKE EELQHKWEAM QQNGALLQNA LTENNIAEIV
SQWTHIPVQK MLQSEKNRVL NIESELQKRV VGQEKAIKAI AKAIKRNKAG LSDSNKPIGS
FLFLGPTGVG KTESAKALAQ FLFDSDKNLI RIDMSEYLEK HAISRLIGAA PGYVGYEEGG
QLTEAVRRKP YSVVLLDEVE KAHPDVFNLL LQVLDEGHLT DSKGVRVDFK NTILILTSNV
ASGALLEEDL SEADKQKAIK ESLRQFFKPE FLNRLDEIIS FNALDSHAVV NIVGILFENI
QKKALERGIN VTLDEEAKEL IAEVGFDRFY GARPLKRALY EMVEDKLAEL ILEDKIKEND
SVAFVVENNE IVPKIK
//
