ID E6PIN6_9ZZZZ Unreviewed; 651 AA.
AC E6PIN6;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN Name=acs {ECO:0000313|EMBL:CBH76327.1};
GN ORFNames=CARN1_0807 {ECO:0000313|EMBL:CBH76327.1};
OS mine drainage metagenome.
OC unclassified sequences; metagenomes; ecological metagenomes.
OX NCBI_TaxID=410659 {ECO:0000313|EMBL:CBH76327.1};
RN [1] {ECO:0000313|EMBL:CBH76327.1}
RP NUCLEOTIDE SEQUENCE.
RA Bertin P.N., Heinrich-Salmeron A., Pelletier E., Goulhen-Chollet F.,
RA Arsene-Ploetze F., Gallien S., Calteau A., Vallenet D., Casiot C.,
RA Chane-Woon-Ming B., Giloteaux L., Barakat M., Bonnefoy V., Bruneel O.,
RA Chandler M., Cleiss J., Duran R., Elbaz-Poulichet F., Fonknechten N.,
RA Lauga B., Mornico D., Ortet P., Schaeffer C., Siguier P.,
RA Alexander Thil Smith A., Van Dorsselaer A., Weissenbach J., Medigue C.,
RA Le Paslier D.;
RT "Diversity of trophic interactions inside an arsenic-rich microbial
RT ecosystem.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CBH76327.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABL01000019; CBH76327.1; -; Genomic_DNA.
DR AlphaFoldDB; E6PIN6; -.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:CBH76327.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 32..82
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 93..478
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 531..609
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 651 AA; 71876 MW; 4D511E3265017890 CRC64;
MESKAIESLL DERRAFPPPP AFAAQANAGP GIYAEAEGDP LAFWAGWARK LHWSRPFTRV
LDWEEPFAQW FADGAINASV NCLDRHVEAG LGARIAYYYE GEPGDRRAIT YRALLEEVCR
FANALRRLGI ERGDRVAIYM PMIPELPVAM LACARIGAAH SVIFGGFSPD AIIDRVNDAE
CVALITADQG WRRGNKVPLK ANCDVAMAQT PSIRHCIVAK RVGDPVTMMP DRDLWWDDLV
ARESTTCEPA QTMAEDLLFL LYTSGTTAKP KGIKHTTGGY LTHVSATHQL VFDLKAERDI
YWCAADIGWV TGHSYIVYGP LCNAATSVIY EGTPDYPEKD RLWEIVERYG VTILYTAPTA
IRTFMKWGTQ HLERHDLSSL RLLGSVGEPI NPEAWIWYRE HVGGGRCPIV DTWWQTETGG
MMISPLPGVT TALPGSATKP LPGISADIVD EAGKSVPLGG GGYIVITQPW PGMTRGIYGD
DERFRETYWS KFPHLYLAGD GCHRDDRGNY WFMGRIDDVM NVSGHRISTA EVESAFVDHP
AVAEAAVCAK NDDVTGQAIY AFVTLRGGFD GTPMLADALR DHVMGKLGKF TRPKYVTFTP
ELPKTRSGKI MRRLLRDIAE GRTLGDTTTL ADSGVVSELQ QRAATDAAKE E
//
