ID E6QZW0_CRYGW Unreviewed; 1165 AA.
AC E6QZW0;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 22-FEB-2023, entry version 62.
DE SubName: Full=Vacuole protein, putative {ECO:0000313|EMBL:ADV20089.1};
GN OrderedLocusNames=CGB_B0710W {ECO:0000313|EMBL:ADV20089.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV20089.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV20089.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP000287; ADV20089.1; -; Genomic_DNA.
DR RefSeq; XP_003191876.1; XM_003191828.1.
DR AlphaFoldDB; E6QZW0; -.
DR GeneID; 10186837; -.
DR KEGG; cgi:CGB_B0710W; -.
DR VEuPathDB; FungiDB:CGB_B0710W; -.
DR eggNOG; KOG0236; Eukaryota.
DR HOGENOM; CLU_003182_0_1_1; -.
DR OrthoDB; 204198at2759; -.
DR Proteomes; UP000007805; Chromosome B.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR43310:SF4; SULFATE TRANSPORTER; 1.
DR PANTHER; PTHR43310; SULFATE TRANSPORTER YBAR-RELATED; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50801; STAS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 362..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 615..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 697..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 750..781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 821..931
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT DOMAIN 1051..1148
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1165 AA; 127303 MW; 480C0E2303CB56B3 CRC64;
MPARDPNASP HLPSTFPTRP VSPTNSHHPN ALSPNNDILS PPAADHQQSH GYFAQALRRV
SGTGGQNLPR MEASAVVGQD VPAERNGWED TSFHTHAGST TSQAIRDSTA RLASVSFSTG
PRAFSSASQG DSSYSHSALS SRHASVNYGP SHSVATSATE HRPIYPSHLN PAIAKLSPTP
VLEDDERDEV SPSKGLQALP ASPFTGAKSG LSMMLERDKE DRRVRGLTEA VSLNSKDSIG
SVGKPASDEE GLGERTPMPR RSSLVDDILQ LPTTDGNARI PHAGSSSSLR RHLANEVNEE
ELGQAPDERS LLLGNGRERK KRPWAGQMLS NVGSWKNNLS KVTARDVAEG IILEPIRTLP
SVILGLLLNV LDGVSYGMIL FPATPIFTDF GSLGVSMFFV SCIVSQLVFS LGGSIFPGGN
GSMMIEAVPF FHILINTFEQ VCGDDHKAVI ATTMVAFAFS SILTGVVFFA LGAFKLGGLI
GYFPRHILVG CIGGVGVFLI ETGLEVSRGL KEEGFEYNLA TLKLFFESGH AIALWTIPLA
LAILLRVITH FWHHQLIFPA YFFIISVIFY IVVAIGRWDL QHLREMGWVF DVGTNKQAWW
KFYTLFDFRK TNWEAFWIAL PTQLALVFFG ILHVPLNVPA LSVSLSEDNV KLDRELIAHG
ASNMLAGLTG TVPNYLTYVN TVLFYRVGGG SRLSGLMLAM GTAAIMMIGP AVIAALPVMV
VGALIFVLGI DLLMEAVWDT RHRVNKMEYI TIWAIAIGMT VFDFVIGLLF GIILACIFFV
VQSSRRRAIR GVFNGATARS TVRRPKWQRS FIQQIGSQTY VMKLQGFLFF GTITNVEDEI
RKLLDLAKWQ HNPIRFLIID FALVHGLDFS SAEAFVRVQR LLAAKDVHLI LCGAKSDGLV
GTALQGVGLW ADREGMRVEV FESLNDALEW TENVYLTAFL ENQQIMDNAT NAKVMDFPKI
AKPPFSLSES FQNSPRRSHL VKAGGDTLFR TSYVSKNDIE SSSPSPEEPL TQPVPVLLQT
FGAYPASSVS SISTSFCKVL APYFTKSSIM SSDTLWTQGD PADGMYIIEV GCLRATYAYN
DTTNLVQETM VAGTMAGDLS ALSETTRNCT VVAERDSVLW KLSKEGLDRM VKEQPEVAQA
FTKMVLKAVA EEQEVLSSHL IAVLS
//
