ID E6R4J7_CRYGW Unreviewed; 759 AA.
AC E6R4J7;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Polynucleotide 5'-hydroxyl-kinase GRC3 {ECO:0000256|ARBA:ARBA00019824};
DE AltName: Full=Polynucleotide 5'-hydroxyl-kinase grc3 {ECO:0000256|ARBA:ARBA00018706};
GN OrderedLocusNames=CGB_D7230C {ECO:0000313|EMBL:ADV22058.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV22058.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV22058.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00011003}.
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DR EMBL; CP000289; ADV22058.1; -; Genomic_DNA.
DR RefSeq; XP_003193845.1; XM_003193797.1.
DR AlphaFoldDB; E6R4J7; -.
DR GeneID; 10189599; -.
DR KEGG; cgi:CGB_D7230C; -.
DR VEuPathDB; FungiDB:CGB_D7230C; -.
DR eggNOG; KOG2750; Eukaryota.
DR HOGENOM; CLU_010345_0_0_1; -.
DR OrthoDB; 5480745at2759; -.
DR Proteomes; UP000007805; Chromosome D.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P; 1.
DR PANTHER; PTHR12755:SF3; POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9; 1.
DR Pfam; PF16575; CLP1_P; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 346..497
FT /note="Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop"
FT /evidence="ECO:0000259|Pfam:PF16575"
FT REGION 1..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 82305 MW; 07D5A1F5B87CAE7F CRC64;
MSALAARRAA EAAANSKPEQ PASSIEKISV PGVLTPPSPK RRKTRQTSPK PPSEAGYSGD
VSSSRQFSLA AESLAEKGTG RFSPSAPSSD NGTSSSSVGD SDEDMAQEDV FEERDMINGA
RDQRKASVTT HMSAPGPSKR LDPVRMDITS QFNPKDNVNL CRITEGQLAS AGINDGHPGP
GVIVSLAQNE SLAIAGLFLL TPLQHALSIY STVLSPSLSS FPVYAPTSHP LPVISPASTQ
ASGISPVLNN IEFPLSFQKD FDRTLLLIRE NRCGIDGLRN GTVPGFSNIW LEDSGSWELR
GVHPVVGSFP VPVYPYYTPP SWSRAISSLS SSDDDLQTPF VGLVKGPKRS GKSTFARALI
NNLLRRFQKV AWLECDLGQG EFGCGAVVGL WILDKPVLGP PFTHPLLPSR SHYLGTYTPL
TCPDEYLAAI RHLIEHYKYE LQYTSEYSAL HTALDDKIGT HVPLVINTQG WMKGLGEDLL
NAIESMAQPT RVFSFESQPE EIYSGQGWTS TPPWQAAQLP YDPAYPTTFP VETESTQTYT
LETAPVSALQ ARYTPADLRV LSTITYFHAS LHPTQSIPVT WDLSSPLVCK IPWEVELGTG
KALEKVYLIG EGSEGVLEED LPIALNGAIV ALAEMLGGYE DQPVVYEQGR SPPPADSINF
LGLAVIRSLS SANSVDSGLK LQLLTPLPPS YLSRVRILIK NGALELPLPG MTDWRRGGIN
EEGMLGKGWE EVPFLDVGGP DIIGGERRRF RKNIMRKGM
//
