ID E6R5S5_CRYGW Unreviewed; 1396 AA.
AC E6R5S5;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Protein-tyrosine-phosphatase, putative {ECO:0000313|EMBL:ADV21663.1};
GN OrderedLocusNames=CGB_D2380C {ECO:0000313|EMBL:ADV21663.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV21663.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV21663.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649}.
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DR EMBL; CP000289; ADV21663.1; -; Genomic_DNA.
DR RefSeq; XP_003193450.1; XM_003193402.1.
DR GeneID; 10191112; -.
DR KEGG; cgi:CGB_D2380C; -.
DR VEuPathDB; FungiDB:CGB_D2380C; -.
DR eggNOG; KOG4228; Eukaryota.
DR HOGENOM; CLU_002713_0_0_1; -.
DR OrthoDB; 1342035at2759; -.
DR Proteomes; UP000007805; Chromosome D.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd18533; PTP_fungal; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF551; TYROSINE-PROTEIN PHOSPHATASE 3; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
FT DOMAIN 447..562
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 808..1039
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 982..1032
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 193..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1092..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1156..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1257..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1300..1396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..219
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1300..1317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1318..1336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1375..1396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1396 AA; 151421 MW; 1BA8AE71475574EA CRC64;
MGIDCRWPPS LLSNWTTCHH SLSLALFSNR KPNRRRRHDG GRPTYAIQPN YCPMTNPANV
EWKELKRSCY YTQPSSVRSP PGRPVGRAFI SFAAPQLSLV RRLLAIRLFP TTPSSYTIHA
SYASPLTIFL SPTHLPSPAF QHPITPFQAD KRTEKNHHSR VYIWSSFFID TITHTNIPSF
ASPALTADVM NRQAPPTLSN FPSASEPRSP PPADPLSPSP AQSPTASSPF RSPGRPSPAR
RSSSGFSLPL QQPNPLTSAN TGFSTPWAAL AASSGAPTPS IEGPMGRNSP HLRSPFERLN
IDGGGNSSSM PRDESPRIQF GESLASPFEG QFRHSASAAS LPLSNKQMST GTGPPVRGGL
SAETLMRYKA IATGAGKPDI GGESAPLAAA RKKNSLPTKL SSTTLGSSTP HSTKSPSPLA
SSVSGSQSPG GMKPQMIAPV DLAKLLRNST TLVLDVRPPS SFQSSHIPSS HSLPIPSTLL
RRPAFTLDKL TQMLSPHSMQ EVSKWQEKSD IVLVDADSGS VPDGGVLDGL AGKFGREGYT
GRLWFVKGGH AAMKLSGALA LVSDDDEEPQ PQQGAAGVGA QKGLMAESTT GSKSSGRQPP
PKGLIIPPTP SLNFQSNPFG SSFPMTTVIS ERPTALRRLG DAPATTNSIA DPTQAKFQPA
NPFFDNIRQN LELSHGGITE RIPLNLPESV KERADQFPDW LRDLVTMPEQ DSMDKLAHQF
YQLELHEQKR LQAIMEWHTK GSGALLQPDV GYEGQTSGGA SEKKNWEWAI QRESDMEELK
RLMNWEQGIK NIEYFPFSIT AGVERGTKNR YKNIWPYDFS RVRLNSPPDK DSDYINASYI
QPRGTSRRYI ATQGPLDATY RDFWTLVWEQ NVRIIVMITK QFEGGLIKCG NYWGEERYGH
IKLQLVSQSG GEDNALPAAN SGFDFGTAGA TPKSSTFPRG SDSNIKRVFL VSRDDKPDQP
PRKVVQLQCI GWPDFDVPEK PDILLKLIQE VNDAACEARP EGCYRKADEP PVLVHCSAGV
GRTGSFIVVD AILDGLRRDL CQRSAPEAQS VDEPACVPEA ISPQHSSSAP PVTTLSTVAS
TEPVCQSFNL GDPNGSVAPQ LSTSPGTMPT PPEHQVAPNL SFPSKERSSD ETMEVDLLKA
TNSVDHRFMQ YRMASVGTSV SSGSDTRRPS LASAQTSSDR ISSESIPGRL SDPHLITSSN
RCRREPSPLS AMRDPVSCVL EGMRVQRMSL VQTLRQYLFV HRAIIYQYLH MLDHDQAKER
PNPSPLQKHA PSFGSSVSGS AIGSLGSLGS FGSIPTTNSA SGGSYTDSLS TNSHGDLTKG
GTDEDSHTKR RASPTELHPD VVLGGEGGSE LSKRPSFKKM KPGTTSGRMG RKSSAMWKGM
EKEAVAEEAV VEELKD
//
