ID E6R696_CRYGW Unreviewed; 1360 AA.
AC E6R696;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=CLASP N-terminal domain-containing protein {ECO:0000259|Pfam:PF12348};
GN OrderedLocusNames=CGB_E6690W {ECO:0000313|EMBL:ADV22706.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV22706.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV22706.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}.
CC -!- SIMILARITY: Belongs to the CLASP family.
CC {ECO:0000256|ARBA:ARBA00009549}.
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DR EMBL; CP000290; ADV22706.1; -; Genomic_DNA.
DR RefSeq; XP_003194493.1; XM_003194445.1.
DR GeneID; 10189686; -.
DR KEGG; cgi:CGB_E6690W; -.
DR VEuPathDB; FungiDB:CGB_E6690W; -.
DR eggNOG; ENOG502S11N; Eukaryota.
DR HOGENOM; CLU_005634_0_0_1; -.
DR OrthoDB; 1378910at2759; -.
DR Proteomes; UP000007805; Chromosome E.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF60; CLASP_N DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776}.
FT DOMAIN 20..240
FT /note="CLASP N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12348"
FT REGION 248..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1053..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1161..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1210..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1336..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..727
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..764
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..900
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..921
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1081..1097
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1180..1194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1218..1267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1360 AA; 146635 MW; A50AC86856E3DAEA CRC64;
MPTITGDTKI PVPTIRHFAD ELDSLAYALE PEEREDTWEK FEKAIIRFTA VTRGGGYQFT
ESYVEGVGRG GVGSKIVRCM LSDRGRLSGV AIELVQTFAP QLGLHFKPLV NLYLEPLVDL
LGRPNKVFLK RAEKCLAVII SNCQIPTILT SLYRGLNDNA ASCRKGCSMG VERALKEWPV
ELWTEKWLVI LEESLKKMAT NKDPDVRKAG KNVWALFMDA WPERVDEFSA PLTPTIKRYL
DISGAGGLSK SKPRCPAPPA RKVLPPLTSS TTSDCNKTLQ RRVNDLLSVP RAAHASSSAF
VTEADPSEKR SSHTEPTMSH EPHCISKAYH EYSRQERSRA LETVSLVSMH AHAPSGAFLH
DVPPSPSNPS AFFSPPVRHE HHTQQVKPKA LSKPVRPTMP TSFSVPALHA NPYSYVSSSS
SGRADEPVRP RRLGQAQRIK VTLPVEGEEG DQEREQREYG RGRDKEGPLR GAVRPITAGM
GGLGKKAGLG RAERRVVTAP LPTASGPLTT GAFEGGAVRL RKKEHNIAVT GEEQAECGST
THAYLPPQEG SAPEAGPRIH HPQPETQQQQ QGFFSPVVAH VLKKNVDSPL LPVLMGSHSR
SPSSSSTPSL ENQLPPTTST PSIAHPSTYV LESASPLEQK DLSKAESQEG EEKNEEEEME
LIKIYLKEVY PLTPPSVKPS SKKKEEVELA KRVELPGSPK KGVEEDGQKE EREDKDGSER
KEKEQEQAPA SISTSNTASV PALASNTTTS APVPPPPPAS IINAPHSRKP PIPTAASSRP
LNPRPRAISG PSVSTKSMNK PPTKPIVRKA FRPTSSTSST SAAATAAVSA SGSGGSHLTA
ATMASRAKVV ATNPSKPVIV TSSVNVSASN TGVGGAAASS TAGRTAKSQY NTAFSSTTSL
AKVKEKEKER TKQEPVRRTE AKKAATTVPA LSRQASTSSM AAASTLANGR ANAMPGRKPP
VPSHVTLPPA KKERIKLKMP LPSFRPARAR PVVAAQFSTS GTEVKGQRVR GKEMRPEMIR
LPDSPPPGGN ESNIKGMGLG VKETTGVVKR EEVPRPADPH EMALPEVPQE SLSLISAETA
LKLEENKEKE REGDKSPTFS STRSARLITL EEMPQSPIKL EKGRPASPLL TTGVEAVYPL
LESGAGFKDR ELRDGDEIKV DNRKVTGNES EGEEEIAIED AYEREQKDER KQDQMGGHLM
QENEIDIFSA PPSDAYSPIY EPSTTSGVSP RPSSPSLPTQ IHTRSPASTS STLSTATPHL
PTHTSSTSRY TLATCNEASA PYNSAITLLL KLESELLIVE SRDVQNFGMS VGDEGILVTP
ERRALAVKDV NTVQTNSVKQ GDKGKGERLG TPEMGLEGDV
//
