ID E6R729_CRYGW Unreviewed; 592 AA.
AC E6R729;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Homoserine o-acetyltransferase {ECO:0000313|EMBL:ADV22498.1};
GN OrderedLocusNames=CGB_E3520W {ECO:0000313|EMBL:ADV22498.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV22498.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV22498.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. MetX family.
CC {ECO:0000256|ARBA:ARBA00006886}.
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DR EMBL; CP000290; ADV22498.1; -; Genomic_DNA.
DR RefSeq; XP_003194285.1; XM_003194237.1.
DR AlphaFoldDB; E6R729; -.
DR GeneID; 10190542; -.
DR KEGG; cgi:CGB_E3520W; -.
DR VEuPathDB; FungiDB:CGB_E3520W; -.
DR eggNOG; ENOG502QR3J; Eukaryota.
DR HOGENOM; CLU_028760_7_1_1; -.
DR OrthoDB; 63733at2759; -.
DR Proteomes; UP000007805; Chromosome E.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR HAMAP; MF_00296; MetX_acyltransf; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR008220; HAT_MetX-like.
DR PANTHER; PTHR32268; HOMOSERINE O-ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR32268:SF16; SERINE O-SUCCINYLTRANSFERASE; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
FT DOMAIN 163..366
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT REGION 1..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..52
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 592 AA; 65631 MW; 4D622EA5E6AB9D43 CRC64;
MTRPPLPRNL NIPRWKPPKP HLAKYHPPPP RPATDFPHFH PPTSPQLPPR RQPAFNPGGF
GLQSQPAPAP APTSFWDKGK ERERQIDEIQ KKDDQLRREE EMIEGKSPKE GREEAEACYV
PPPATLHYVA SHSLPLLYSP SPLPPFTIAY ETWGTLNSDA SNAILLHTGL SASSHVASRG
NDVSPSTSSK PGWWEDFVGP GKSIDTDKFF VICTNVLGGC FGSTGPSSPY PPGEGETRWA
TRFPLLSIHD MTRAQISLMD HLGINKLYAS IGSSMGGMQS LSLAYLAPER VGRIVSISAC
GRSGLNGVGM RYAQRSVLMA DPNWNRGFYY DGVPPHNGMK LARQIATITY RSGPEWEQRF
GRQMISEQDA QLDAQGNPGV PRLSPDFLIE TYLDHQVSLC SCHFFLHQLT YVFFFNPKGE
RFCLTYDANS LIYISKAMDL FDMTGQALTA LAKRFNDAYP DSAPFPYPDD PISVSCCAPR
GAAEAHQHTP EEQERLEKET KKKLARFIPT SKSPHLGDLA QGLQRLKDIP TLVLGVQSDV
LFPVEQQREL SDALKLTGNS KVTYYELGGV WGHDTFLLDV QNVGGAIRGF LH
//
