ID E6R954_CRYGW Unreviewed; 606 AA.
AC E6R954;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=RNA lariat debranching enzyme, putative {ECO:0000313|EMBL:ADV23329.1};
GN OrderedLocusNames=CGB_G1570W {ECO:0000313|EMBL:ADV23329.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV23329.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV23329.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the lariat debranching enzyme family.
CC {ECO:0000256|ARBA:ARBA00006045}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000292; ADV23329.1; -; Genomic_DNA.
DR RefSeq; XP_003195116.1; XM_003195068.1.
DR AlphaFoldDB; E6R954; -.
DR GeneID; 10188937; -.
DR KEGG; cgi:CGB_G1570W; -.
DR VEuPathDB; FungiDB:CGB_G1570W; -.
DR eggNOG; KOG2863; Eukaryota.
DR HOGENOM; CLU_005893_1_0_1; -.
DR OrthoDB; 1220605at2759; -.
DR Proteomes; UP000007805; Chromosome G.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008419; F:RNA lariat debranching enzyme activity; IEA:UniProt.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR CDD; cd00844; MPP_Dbr1_N; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR007708; DBR1_C.
DR InterPro; IPR041816; Dbr1_N.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR PANTHER; PTHR12849:SF0; LARIAT DEBRANCHING ENZYME; 1.
DR PANTHER; PTHR12849; RNA LARIAT DEBRANCHING ENZYME; 1.
DR Pfam; PF05011; DBR1; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SMART; SM01124; DBR1; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 438..599
FT /note="Lariat debranching enzyme C-terminal"
FT /evidence="ECO:0000259|SMART:SM01124"
FT REGION 243..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 606 AA; 67392 MW; 45C602E3A337D0EA CRC64;
MRIAIQGCSH GSLAQIYDVI NYYSSQTKNP IDLLLLCGDF QALRSKHDYA SLAVPAKFKQ
LGSFHQYYSG ERVAPVLTIV IGGNHEASNY MWELYHGGWL APSIYYLGAA GSVYVNGLRI
VGASGIYKGF DYRKGHFEKV PYNDKELRSV YHIREYDVEK LMHLTPTPST IFLSHDWPTT
IAHHGNKHAL LKRKPFFRDE IEKNTLGSPP LLRLMNHFQP SYWFSAHLHV KFAALYEHQA
PNHGPDVDDS TSLPLPATSS TVTQAGGNPD EIQIDEEMDE GNPDEIIIED EGEEIIVRPR
QANPDEIVMD DEEFDDTEPA VPQPLPSATN NTFNPEEITI SDEEFDAPTA ISQTPQPLPV
TKANPSNPEE ITISDDEFND STPAAQPLTT IDESTDLIAQ SRSNPSHPPV PGTIAPSASD
STASRIMQEA REEQQKWELH GGKGMEGVTK FLALDKCGPG KDHMQFLEIP DPSPPSFPAP
PRLTYDPEWL AICRAFHPYL STSYQPIPLP SSDVLGQMVK DEITRIKEEG LLVPTEPQDG
AIEGQEGLIW EKGKVDVGRV QRFWWTAPPE GHPGGNDAAW YTNPQTEAFC GMLGVQNKIN
PPVNRQ
//
