ID E6RCG5_CRYGW Unreviewed; 622 AA.
AC E6RCG5;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Histone deacetylase 1 (Hd1), putative {ECO:0000313|EMBL:ADV24474.1};
GN OrderedLocusNames=CGB_I4200W {ECO:0000313|EMBL:ADV24474.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV24474.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV24474.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
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DR EMBL; CP000294; ADV24474.1; -; Genomic_DNA.
DR RefSeq; XP_003196261.1; XM_003196213.1.
DR AlphaFoldDB; E6RCG5; -.
DR GeneID; 10186573; -.
DR KEGG; cgi:CGB_I4200W; -.
DR VEuPathDB; FungiDB:CGB_I4200W; -.
DR eggNOG; KOG1342; Eukaryota.
DR HOGENOM; CLU_007727_7_13_1; -.
DR OrthoDB; 1327607at2759; -.
DR Proteomes; UP000007805; Chromosome I.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF5; HISTONE DEACETYLASE; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 4: Predicted;
FT DOMAIN 112..379
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 68133 MW; 6790AAF455993CAF CRC64;
MGPAQPPIDP SPPPSSSSSR RVAYYYDQDV GNYNYYLGHP MKPHRIRMAH NLIVNYGMCD
EEGQEHGPAE VWGEGKRMVN DEMAQNWGGG LMGEAEMKWE KAALSGSRSK MMQVFKPRRA
TKEEMTRFHT DEYIDLLEAV TPETADALTG GGTRCLIGED CPAFDGLFEF CTISAGGSLG
AAERLNAGAA DIVINWAGGL HHAKKTEASG FCYVNDIVLG ILELLRIHPR VLYIDVDVHH
GDGVEEAFYV TDRVMTCSFH RFGEFFPGTG DVRDVGMKKG KGYAVNVPLR DGITDETFQS
IFKPVIDRIM SHFRPSAVVL QMGADSISGD KLGGFNLTLE GHAECARFIK GFNVPVMMVG
GGGYTVKNVA RAWTKETAIM CGVDLPEDLP YNQFLEYYGP RYKLEVLPTN AVDHNPPEYL
ERIKNQVFEN LRNLPFAPSA QMRSVPSKTI GQVLGITDGG DEEPEDEIDQ RIKKLLKRRR
ANALDGDVSS SSESEIDTPA FSRPGRARRQ GGNFSGRGRS SRLAQLQHNR ERREAAQEAS
NGMEDDPCGV LGKKKRSFFK VVPKLNGVGV EPVDTSAVGF GIGVVNGGFN GVGLKERLGI
PVVEQWKGNG VMSRAGTPAS MA
//
