ID E6RDI1_CRYGW Unreviewed; 555 AA.
AC E6RDI1;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Prenylcysteine lyase domain-containing protein {ECO:0000259|Pfam:PF07156};
GN OrderedLocusNames=CGB_K2060C {ECO:0000313|EMBL:ADV24950.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV24950.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV24950.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the prenylcysteine oxidase family.
CC {ECO:0000256|ARBA:ARBA00009967}.
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DR EMBL; CP000296; ADV24950.1; -; Genomic_DNA.
DR RefSeq; XP_003196737.1; XM_003196689.1.
DR AlphaFoldDB; E6RDI1; -.
DR GeneID; 10185205; -.
DR KEGG; cgi:CGB_K2060C; -.
DR VEuPathDB; FungiDB:CGB_K2060C; -.
DR eggNOG; ENOG502QSHJ; Eukaryota.
DR HOGENOM; CLU_021176_0_0_1; -.
DR OrthoDB; 1334100at2759; -.
DR Proteomes; UP000007805; Chromosome K.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:UniProt.
DR GO; GO:0001735; F:prenylcysteine oxidase activity; IEA:InterPro.
DR GO; GO:0030328; P:prenylcysteine catabolic process; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR010795; Prenylcys_lyase.
DR InterPro; IPR017046; Prenylcysteine_Oxase.
DR PANTHER; PTHR15944; FARNESYLCYSTEINE LYASE; 1.
DR PANTHER; PTHR15944:SF0; PRENYLCYS_LYASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR Pfam; PF07156; Prenylcys_lyase; 1.
DR PIRSF; PIRSF036292; Prenylcysteine_oxidase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 179..537
FT /note="Prenylcysteine lyase"
FT /evidence="ECO:0000259|Pfam:PF07156"
SQ SEQUENCE 555 AA; 61802 MW; B0C319C5B4251ADE CRC64;
MPPLSLTSSS TRFRIGFFVL LAISFSFIYH FAPSFSSHRS TSQNEQTGSS EYLIDVNSGK
LQGQNRKRIA IVGAGASGSS AAFFLRRAAN VIERRAGLAE STLIGDILVY EKEGYVGGRT
TTIYPHDDDR ARPQELGASI FVDSNVNLMK AVREFNLTLV DPNFGGSGVG IWDGQKFLFT
SSSSSWITSA RALLRYGPLS PFRTRHAISS LLKKFMRLYD PSWLHDRGVT DSIEEFVEAV
GLGREYTTRS GESWAREVVR AGERWVGEVW EGNTRTNYAM NIDKIHALAA GFSMATGGAS
QVEGGNYQIF QSMLADAGAR LYLGTLVEDI IPQEKDGSRR FVIKTNRTEL ANEEVDHVFW
AAPWRLQGMK SLEKEFIEPM PPIPYVRLHV TYLTTTQKHP APSFFGLPSE STIPTTILTS
AHPPRSPNAP SLPPPKFQSI TWHGESFPGS NEYAVKIISL TRLSDRFLKG ILGDEPTWVK
RKEWDSYPKM EPFAGYAPVK LTEGVEYLAG MERWVSTMET QTVSAREAVA RVAQKWWGLG
LGECENGDSW DWTCS
//
