ID E6RG07_CRYGW Unreviewed; 864 AA.
AC E6RG07;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Membrane protein, putative Rsn1p {ECO:0000313|EMBL:ADV25717.1};
GN OrderedLocusNames=CGB_N1470C {ECO:0000313|EMBL:ADV25717.1};
OS Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV25717.1, ECO:0000313|Proteomes:UP000007805};
RN [1] {ECO:0000313|EMBL:ADV25717.1, ECO:0000313|Proteomes:UP000007805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WM276;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwong-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 0:0-0(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; CP000299; ADV25717.1; -; Genomic_DNA.
DR RefSeq; XP_003197504.1; XM_003197456.1.
DR AlphaFoldDB; E6RG07; -.
DR GeneID; 10186507; -.
DR KEGG; cgi:CGB_N1470C; -.
DR VEuPathDB; FungiDB:CGB_N1470C; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_2_0_1; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000007805; Chromosome N.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF143; PHOSPHATE METABOLISM PROTEIN 7; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 16..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 523..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 684..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 716..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..168
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 254..417
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 428..703
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 792..855
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 757..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 95153 MW; 495AE8975680ED4D CRC64;
MSATNADVQS STTGSFVAAL VVAGITVGGF STLWLVLHGR KDLQRVFQPR TILPPEGKRP
QPLPSGIIAF WKTLFKTPDQ DIIVSNGPDA YFYVRFLKVF GLQMLIPYVI LTCAILIPVS
AVSPNQGMQG LNILTFGNVA SSDQVRHVAH FLVTIILMSW TVFLIWREYN HFVDVRQTWM
TTPQHLSLAR ARTIAITNIP ESINSSTGIK ELAGLVSRVG AGNGSGTNLL ALTNPFSRQS
IATENTGANA DSEGGVRHVW LTRKCKGIEK VWKERDAECA RLEGGVAKLQ KRAAKNVRKG
KTPMQQGKFD AESSGGDLID GYVLPKKRPS WKQGLLGLIG KKQNLDTSPE YILEHNAKLD
ELREGTENLP QGNTAFIRFS SQFEAHAFAK LASKTDKSNM FIRGGVELVP EDIEWSNISM
SPYERQIRTI VSWCLTVGLI IVWAIPVAFV GMVSNIDTLC ANASWLAWVC TLPSPALAII
KGVLPPALLA VLFMLLPVVL RLMVKMQGEI RKSDIELRLF SRFWLFQVIH GFLIVTLASG
LMNALGNLGN TASQVPTLLA DKLPGASIFF LTFILTATFS GAAKTYSRLV PWIMYLLRNI
LAGGTPRKAY MKKYKMDSFA WATAFPPTCL IMCVTIVYSV IQPIITALAW VAFILLYFAN
KYVIHWCADQ PDAGETGGQF YIKALRTIFV SLYIQGVCMA GLFFLSTNEN GSRSKTGLGC
GAVMCVMIIC IALIQIYIDW FRFTKPYLIY VHRTPSVPNS SSVEPKVGRG GVTDSPSDED
ALAGPELGNT SGFHERAFDH PALWKKQPVI WVAVDPHGLG ALEVERINDK GVEASLEYAV
MNEKGQIDVQ RSPPDEAWYE GFTA
//
