ID E6SKD6_THEM7 Unreviewed; 675 AA.
AC E6SKD6;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:ADU52294.1};
DE EC=2.4.1.129 {ECO:0000313|EMBL:ADU52294.1};
GN OrderedLocusNames=Tmar_2214 {ECO:0000313|EMBL:ADU52294.1};
OS Thermaerobacter marianensis (strain ATCC 700841 / DSM 12885 / JCM 10246 /
OS 7p75a).
OC Bacteria; Bacillota; Clostridia; Eubacteriales;
OC Clostridiales Family XVII. Incertae Sedis; Thermaerobacter.
OX NCBI_TaxID=644966 {ECO:0000313|EMBL:ADU52294.1, ECO:0000313|Proteomes:UP000008915};
RN [1] {ECO:0000313|EMBL:ADU52294.1, ECO:0000313|Proteomes:UP000008915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a
RC {ECO:0000313|Proteomes:UP000008915};
RX PubMed=21304738;
RA Han C., Gu W., Zhang X., Lapidus A., Nolan M., Copeland A., Lucas S.,
RA Del Rio T.G., Tice H., Cheng J.F., Tapia R., Goodwin L., Pitluck S.,
RA Pagani I., Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Schneider S., Rohde M., Goker M., Pukall R., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA Detter J.C.;
RT "Complete genome sequence of Thermaerobacter marianensis type strain
RT (7p75a).";
RL Stand. Genomic Sci. 3:337-345(2010).
RN [2] {ECO:0000313|Proteomes:UP000008915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700841 / DSM 12885 / JCM 10246 / 7p75a
RC {ECO:0000313|Proteomes:UP000008915};
RX DOI=10.4056/sigs.1373474;
RA Han C., Gu W., Zhang X., Lapidus A., Nolan M., Copeland A., Lucas S.,
RA Glavina Del Rio T., Tice H., Cheng J., Tapia R., Goodwin L., Pitluck S.,
RA Pagani I., Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y., Jeffries C., Schneider S.,
RA Rohde M., Goker M., Pukall R., Woyke T., Bristow J., Eisen J.,
RA Markowitz V., Hugenholtz P., Kyrpides N., Klenk H., Detter J.;
RT "Complete genome sequence of Thermaerobacter marianensis type strain
RT (7p75aT).";
RL Stand. Genomic Sci. 3:337-345(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002344; ADU52294.1; -; Genomic_DNA.
DR RefSeq; WP_013496594.1; NC_014831.1.
DR AlphaFoldDB; E6SKD6; -.
DR STRING; 644966.Tmar_2214; -.
DR KEGG; tmr:Tmar_2214; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_2_9; -.
DR OrthoDB; 9757901at2; -.
DR Proteomes; UP000008915; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000313|EMBL:ADU52294.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008915};
KW Transferase {ECO:0000313|EMBL:ADU52294.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..227
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 290..640
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 675 AA; 73610 MW; 7B23FAD05BDC4E2C CRC64;
MNPEERARRQ RVRRRNVLMA LLVIWTVILL GRLYVLQVVM GDELSEYAAG QRLRKVYVPA
PRGQIVDRRG QVLATTLPAY SAYLVYTRDG LDPEARQLLS RILNIPVEAI EAAEAQLRVR
PVPEIPVRLK AELTPAEITA LAENRDRLPG VIVEPQPLRY YPGGTLAAHV LGYVREGERP
WQLRGETGIE LTYNGQVELP GGRTVRGLTG VDGQRLVEVD ARGRPLADAS RYLLLGGDAE
RYAVPPQPGN TVVLTLDARV QKAAEEALAR RIQELRQLKT RPCPCPARNG AAVAIDVRTG
AILAMASYPT FDPNDFARQA FMEKSDPRYP AVNRRVQSYF EETKYRGRRV LGATMNMAIR
VPLAPGSTFK PVTALAAMLR GALPGSLYCN GRFPFAGGVW EDWQAHGYVD FNRAIGRSCN
VYFYQAGLNT GIEAIDQVAT QFGLGQPTGL RDLPGERAGT LASPEVKAKV NPKDPRWYAG
DTLNTSIGQG LNAFTPLQMA VYTATLANGG TRYRPYLVQE IRDPQTGRVL WEAKPDPLNT
VDIPTAFLER VRQAMVTVTR DNGGWYGTAY GVFRDAPYVA AGKTGTAQAG SDLPEYENHG
WFIAFAPAGP GEEPEIAVAV VIHAGGGGAL AAGPVARAVL DAYFAGRYGL TENPVEAAQE
ARQNAARSVT TVPAD
//
