ID   E6TFR9_MYCSR            Unreviewed;       763 AA.
AC   E6TFR9;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Glycine cleavage system T protein (Aminomethyltransferase) {ECO:0000313|EMBL:ADU01106.1};
GN   OrderedLocusNames=Mspyr1_45540 {ECO:0000313|EMBL:ADU01106.1};
OS   Mycolicibacterium gilvum (strain DSM 45189 / LMG 24558 / Spyr1)
OS   (Mycobacterium gilvum).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=278137 {ECO:0000313|EMBL:ADU01106.1, ECO:0000313|Proteomes:UP000008916};
RN   [1] {ECO:0000313|Proteomes:UP000008916}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45189 / LMG 24558 / Spyr1
RC   {ECO:0000313|Proteomes:UP000008916};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., LaButti K., Ivanova N.M., Mikhailova N.M., Land M., Hauser L.,
RA   Koukkou A.I., Drainas C., Kyrpides N., Woyke T.;
RT   "Complete sequence of chromosome of Mycobacterium sp. Spyr1.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADU01106.1, ECO:0000313|Proteomes:UP000008916}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45189 / LMG 24558 / Spyr1
RC   {ECO:0000313|Proteomes:UP000008916};
RX   PubMed=22180818;
RA   Kallimanis A., Karabika E., Mavromatis K., Lapidus A., Labutti K.M.,
RA   Liolios K., Ivanova N., Goodwin L., Woyke T., Velentzas A.D.,
RA   Perisynakis A., Ouzounis C.C., Kyrpides N.C., Koukkou A.I., Drainas C.;
RT   "Complete genome sequence of Mycobacterium sp. strain (Spyr1) and
RT   reclassification to Mycobacterium gilvum Spyr1.";
RL   Stand. Genomic Sci. 5:144-153(2011).
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DR   EMBL; CP002385; ADU01106.1; -; Genomic_DNA.
DR   AlphaFoldDB; E6TFR9; -.
DR   KEGG; msp:Mspyr1_45540; -.
DR   HOGENOM; CLU_019604_0_0_11; -.
DR   Proteomes; UP000008916; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   InterPro; IPR018959; DUF1989.
DR   InterPro; IPR028896; GCST/YgfZ/DmdA.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR   PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   Pfam; PF09347; DUF1989; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR   SUPFAM; SSF103025; Folate-binding domain; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:ADU01106.1};
KW   Transferase {ECO:0000313|EMBL:ADU01106.1}.
FT   DOMAIN          166..334
FT                   /note="DUF1989"
FT                   /evidence="ECO:0000259|Pfam:PF09347"
FT   DOMAIN          393..648
FT                   /note="Aminomethyltransferase folate-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01571"
FT   DOMAIN          674..755
FT                   /note="Glycine cleavage T-protein C-terminal barrel"
FT                   /evidence="ECO:0000259|Pfam:PF08669"
SQ   SEQUENCE   763 AA;  82985 MW;  2BD9F3FCB42BE1E2 CRC64;
     MVQRFRVAPG SVTAVPVFGG DRFDIVDQYG RQPAELTVLA ADPRAVADAP PDTAATVLRS
     LIPGSDENGY AAQRILSLLA GHRVDQQEAV ATRLFGHHSP AGSRATFTVD ADAVVLVAAP
     ASPMHPHSDD PNPPSEVRVA VYRADPGRPA TPELPPPLAE PLLDRRIDAE TAASYEVREG
     QFIQIIDVAG RQCSDFLAFD ARGLADGREY GLDATTTRTI GGAAYPRPGL FGKFFDARAR
     PLVEVVRDTV GRHDTFALAC TAKYYADLGY LGHVNCTDNF NGALARFGVD RRQGWPALNL
     FYNTAFDAAH QLISDEPWSR AGDYVLFRAS ADLVCASSAC PDDIDPANGW VPTDIHVRVY
     DSSRRFSVAV GHRLTPDSEP VLTKSTAFAR RTGALTTDFT EYNGYWLPNS YANHGPHDEY
     WACRERVAVM DLSALRKFEV LGPDAEALLQ ATLTRDIRRL SRGQVVYSAM CSESGGVVDD
     CTVLRLGDNN FRFIGGDPHG GVWLRTQAER LGLHQVWIKD STDQMHNLAI QGPASRAVLD
     GLIWTPPGQP ALRDLGWFRF LTGRLDGPDG APLLVSRTGY TGELGYEVWV HPGDAETLWD
     RLWDAGRPHG LTPLGLEALE MVRIEAGLVA GGHEFDDQTD PFEAGIGFTV PLKTKTDDFV
     GRAALVERKA HPQRTLVGLR LDSNETTAQG DCVHLGRTQV GVVTSATRSP LLGASIALCR
     IAVQHSEPGT RVEIGKLDGH LKRIPATVTT IPFYDPDKTR PRS
//