ID E6TKH6_MYCSR Unreviewed; 249 AA.
AC E6TKH6;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Thioesterase TesA {ECO:0000256|ARBA:ARBA00015007};
GN OrderedLocusNames=Mspyr1_49070 {ECO:0000313|EMBL:ADU01442.1};
OS Mycolicibacterium gilvum (strain DSM 45189 / LMG 24558 / Spyr1)
OS (Mycobacterium gilvum).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=278137 {ECO:0000313|EMBL:ADU01442.1, ECO:0000313|Proteomes:UP000008916};
RN [1] {ECO:0000313|Proteomes:UP000008916}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45189 / LMG 24558 / Spyr1
RC {ECO:0000313|Proteomes:UP000008916};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., LaButti K., Ivanova N.M., Mikhailova N.M., Land M., Hauser L.,
RA Koukkou A.I., Drainas C., Kyrpides N., Woyke T.;
RT "Complete sequence of chromosome of Mycobacterium sp. Spyr1.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADU01442.1, ECO:0000313|Proteomes:UP000008916}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45189 / LMG 24558 / Spyr1
RC {ECO:0000313|Proteomes:UP000008916};
RX PubMed=22180818;
RA Kallimanis A., Karabika E., Mavromatis K., Lapidus A., Labutti K.M.,
RA Liolios K., Ivanova N., Goodwin L., Woyke T., Velentzas A.D.,
RA Perisynakis A., Ouzounis C.C., Kyrpides N.C., Koukkou A.I., Drainas C.;
RT "Complete genome sequence of Mycobacterium sp. strain (Spyr1) and
RT reclassification to Mycobacterium gilvum Spyr1.";
RL Stand. Genomic Sci. 5:144-153(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+);
CC Xref=Rhea:RHEA:16781, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:57287, ChEBI:CHEBI:77636;
CC Evidence={ECO:0000256|ARBA:ARBA00024293};
CC -!- SIMILARITY: Belongs to the thioesterase family.
CC {ECO:0000256|ARBA:ARBA00007169}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002385; ADU01442.1; -; Genomic_DNA.
DR RefSeq; WP_013472987.1; NC_014814.1.
DR AlphaFoldDB; E6TKH6; -.
DR ESTHER; mycgi-a4t632; Thioesterase.
DR KEGG; msp:Mspyr1_49070; -.
DR HOGENOM; CLU_070456_1_2_11; -.
DR Proteomes; UP000008916; Chromosome.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR012223; TEII.
DR InterPro; IPR001031; Thioesterase.
DR PANTHER; PTHR11487:SF0; S-ACYL FATTY ACID SYNTHASE THIOESTERASE, MEDIUM CHAIN; 1.
DR PANTHER; PTHR11487; THIOESTERASE; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 24..245
FT /note="Polyketide synthase thioesterase"
FT /evidence="ECO:0000259|SMART:SM00824"
SQ SEQUENCE 249 AA; 27506 MW; D01D46456E56D7F8 CRC64;
MTQPPRSRWL RNFHPAPSAR TRLVCLPHAG GSASYYFPMS AALSPEFNVY GVQYPGRQDR
HSEPFVESVD DLADQIYAEV AALPEVPTAF FGHSMGAVLA FEVARRFESL AGRRPVVVFA
SGSRAPSHYG DEREYKSDND LIGVMRDLGG TDPRIFNDPD LLSTFLPAFR NDYRALQAYH
RGTEVVISAP IVVMTATDDP KTSEDGARAW LAHTTGGGEV RTFTGGHFYL EKQPQKVIDV
VTQTLRDVG
//
