ID E6TLF2_MYCSR Unreviewed; 770 AA.
AC E6TLF2;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase {ECO:0000313|EMBL:ADU00437.1};
GN OrderedLocusNames=Mspyr1_38430 {ECO:0000313|EMBL:ADU00437.1};
OS Mycolicibacterium gilvum (strain DSM 45189 / LMG 24558 / Spyr1)
OS (Mycobacterium gilvum).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=278137 {ECO:0000313|EMBL:ADU00437.1, ECO:0000313|Proteomes:UP000008916};
RN [1] {ECO:0000313|Proteomes:UP000008916}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45189 / LMG 24558 / Spyr1
RC {ECO:0000313|Proteomes:UP000008916};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., LaButti K., Ivanova N.M., Mikhailova N.M., Land M., Hauser L.,
RA Koukkou A.I., Drainas C., Kyrpides N., Woyke T.;
RT "Complete sequence of chromosome of Mycobacterium sp. Spyr1.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADU00437.1, ECO:0000313|Proteomes:UP000008916}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45189 / LMG 24558 / Spyr1
RC {ECO:0000313|Proteomes:UP000008916};
RX PubMed=22180818;
RA Kallimanis A., Karabika E., Mavromatis K., Lapidus A., Labutti K.M.,
RA Liolios K., Ivanova N., Goodwin L., Woyke T., Velentzas A.D.,
RA Perisynakis A., Ouzounis C.C., Kyrpides N.C., Koukkou A.I., Drainas C.;
RT "Complete genome sequence of Mycobacterium sp. strain (Spyr1) and
RT reclassification to Mycobacterium gilvum Spyr1.";
RL Stand. Genomic Sci. 5:144-153(2011).
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DR EMBL; CP002385; ADU00437.1; -; Genomic_DNA.
DR RefSeq; WP_013472338.1; NC_014814.1.
DR AlphaFoldDB; E6TLF2; -.
DR KEGG; msp:Mspyr1_38430; -.
DR HOGENOM; CLU_000445_129_3_11; -.
DR Proteomes; UP000008916; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 363..496
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 501..752
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
FT REGION 750..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 770 AA; 82474 MW; CDDBDFA24B3E4C3E CRC64;
MTGYRIRASV VLAATLLVLV NGFAPWGQAA ALRVDAILQV CTAAVAVVYG LWVARRVHGV
SRTWRLLAVG AVAGLLVGEL VWWEPTEALP VAWVIPYWLF LILALASMVV LARAGRGMSI
PADGSLRHTA VITVLDAGVA AASFAILVFL GRYGAFSVSS WPHSTDPSVE IGYAVFQLVV
VVIAAVVGMM YAADRPFRSN FLQLACGVVM AISSDRVIAY FDSVGNEGAQ IWAGVGVVLG
PLLIAFSFRE RTDGIRGPTD TMRPMDWAQM TLPYAGFIGI TNLLSYHVLT GNTLDPAVVM
TTLVMVILVA ARQVVAMGAQ RRLTQRLYEA QRGLAHQVHH DALTGLPNRL MFAQRLEAAV
QHGDFVLIFV DLDDFKEVND RFGHAAGDEL LCAVGERLRR HVRSEDTLAR IGGDEFAILI
DGVRDIPELI ADRLRVALRD PFPVHGSSLR VRASMGLVRS GGEGGLQTPD DLLRQADISM
YAGKRLGKDT AVVYQPSAGV RAEFPAALRE AQGGVPDGFA LAYQPVVHLP DQTPAALEAL
ARWTAPNGIL IAPETFVAVA EASGLGATLD AMVLGLACRE VKDAGLDVDI HVNVGAARLG
NPTFEEQVHR TFDECGMEPS RLVLEITETV PIVDLADAAA QIERFKALGI RIALDDFGAG
YNSLTYLHAL PVDIVKLDRS LAVGADPERD LALYRSVIGL CTDLGMDVVA EGIETQLQAD
TVYAAGCAFA QGHLFGKPVA ISELTRGWHE PSGQIGGGGR EVNQPTNQPT
//
