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Database: UniProt
Entry: E6UCH1_RUMA7
LinkDB: E6UCH1_RUMA7
Original site: E6UCH1_RUMA7 
ID   E6UCH1_RUMA7            Unreviewed;       907 AA.
AC   E6UCH1;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-SEP-2017, entry version 40.
DE   RecName: Full=Endoglucanase {ECO:0000256|RuleBase:RU361166};
DE            EC=3.2.1.4 {ECO:0000256|RuleBase:RU361166};
DE   Flags: Precursor;
GN   OrderedLocusNames=Rumal_1050 {ECO:0000313|EMBL:ADU21576.1};
OS   Ruminococcus albus (strain ATCC 27210 / DSM 20455 / JCM 14654 / NCDO
OS   2250 / 7).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae;
OC   Ruminococcus.
OX   NCBI_TaxID=697329 {ECO:0000313|EMBL:ADU21576.1, ECO:0000313|Proteomes:UP000006919};
RN   [1] {ECO:0000313|EMBL:ADU21576.1, ECO:0000313|Proteomes:UP000006919}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27210 / DSM 20455 / JCM 14654 / NCDO 2250 / 7
RC   {ECO:0000313|Proteomes:UP000006919};
RX   PubMed=21914885; DOI=10.1128/JB.05621-11;
RA   Suen G., Stevenson D.M., Bruce D.C., Chertkov O., Copeland A.,
RA   Cheng J.F., Detter C., Detter J.C., Goodwin L.A., Han C.S.,
RA   Hauser L.J., Ivanova N.N., Kyrpides N.C., Land M.L., Lapidus A.,
RA   Lucas S., Ovchinnikova G., Pitluck S., Tapia R., Woyke T., Boyum J.,
RA   Mead D., Weimer P.J.;
RT   "Complete genome of the cellulolytic ruminal bacterium Ruminococcus
RT   albus 7.";
RL   J. Bacteriol. 193:5574-5575(2011).
CC   -!- CATALYTIC ACTIVITY: Endohydrolysis of (1->4)-beta-D-glucosidic
CC       linkages in cellulose, lichenin and cereal beta-D-glucans.
CC       {ECO:0000256|RuleBase:RU361166}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 9 (cellulase E)
CC       family. {ECO:0000256|RuleBase:RU361166}.
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DR   EMBL; CP002403; ADU21576.1; -; Genomic_DNA.
DR   RefSeq; WP_013497754.1; NZ_JHYT01000025.1.
DR   ProteinModelPortal; E6UCH1; -.
DR   STRING; 697329.Rumal_1050; -.
DR   EnsemblBacteria; ADU21576; ADU21576; Rumal_1050.
DR   KEGG; ral:Rumal_1050; -.
DR   eggNOG; ENOG4105E08; Bacteria.
DR   eggNOG; ENOG410XNTA; LUCA.
DR   HOGENOM; HOG000245359; -.
DR   KO; K01179; -.
DR   OMA; YPWHTCE; -.
DR   OrthoDB; POG091H04TS; -.
DR   BioCyc; RALB697329:GIWQ-1042-MONOMER; -.
DR   Proteomes; UP000006919; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008810; F:cellulase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030245; P:cellulose catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd02850; E_set_Cellulase_N; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase-like.
DR   InterPro; IPR004197; Cellulase_Ig-like.
DR   InterPro; IPR003305; CenC_carb-bd.
DR   InterPro; IPR008979; Galactose-bd-like.
DR   InterPro; IPR001701; Glyco_hydro_9.
DR   InterPro; IPR033126; Glyco_hydro_9_Asp/Glu_AS.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   Pfam; PF02018; CBM_4_9; 1.
DR   Pfam; PF02927; CelD_N; 1.
DR   Pfam; PF00759; Glyco_hydro_9; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00698; GLYCOSYL_HYDROL_F9_2; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|RuleBase:RU361166};
KW   Cellulose degradation {ECO:0000256|RuleBase:RU361166};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006919};
KW   Glycosidase {ECO:0000256|RuleBase:RU361166,
KW   ECO:0000313|EMBL:ADU21576.1};
KW   Hydrolase {ECO:0000256|RuleBase:RU361166,
KW   ECO:0000313|EMBL:ADU21576.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Polysaccharide degradation {ECO:0000256|RuleBase:RU361166};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006919};
KW   Signal {ECO:0000256|RuleBase:RU361166};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     30       {ECO:0000256|RuleBase:RU361166}.
FT   CHAIN        31    907       Endoglucanase. {ECO:0000256|RuleBase:
FT                                RU361166}.
FT                                /FTId=PRO_5005128263.
FT   TRANSMEM    872    894       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       36    176       CBM-cenC. {ECO:0000259|Pfam:PF02018}.
FT   DOMAIN      218    295       CelD_N. {ECO:0000259|Pfam:PF02927}.
SQ   SEQUENCE   907 AA;  99885 MW;  FF4B98A1090D9492 CRC64;
     MFIRPTKRIA SAAAASVLFL NSAAPLCVFA GQQLGQTDFD DGVGLPWHIC ESRTAEMDFD
     ISDGKYKITI VNPGGASNGG EDRWDCQFRH RGLKIVSGHQ YKVSYEITPS KSGKYYTKIG
     NLDGDVEVWH NMSNGYDLDG TWDPIPISAK ETKKVELTFT ASQSLDVAEW AFHLGGDGQY
     TQGGCFPAGT EITFDNMSLI DLTSDENDYQ VPEKWVRADI LTNQVGYFAK REKKATLLCT
     DKDAIGFEVV DDSGKTVYEG KSEYFGYDED SEDTVHIIDF SELDESGTFH IEADNGAESR
     EFKVFAADEV SDYSALLYDS LNYFYQNRSG IEIESEYISS GDKSDLARAA GHTSDDAEIQ
     HTWGYSATSG RVDVTGGWYD AGDHGKYTVN GGLSLWMLQN LYEFFVYTGN EDIFADGSMI
     IPESGNGFPD LLDEARWEME WMLKMQLDTS EYEGMAYHKA HDETWTGLGV APADDDKNRI
     IKPPTTAATL NLAACAAQSA RLWEDLDSDF ADTCLEAAEK AYAAAKKHPE MYAPLDESVG
     GGAYGDNDVE DEFYWAAMEL YAATGEKDYL KDAEKSDYYM SVPVSMGSGE SVDSTGTFDW
     GNTAALGTFT ALLNENTFDD ADEAEKSLRE AADHYITLEE KQGYGLPYGQ STLSYNDSDK
     GYLWGSNSFV ADNAIVLAYA AVLNEDDSYT DGALQGLDYL LGRNAMDYSY VTGYGSHTTE
     NPHHRWWSNQ IDDKFPKAPC GVLSGGPNSG MQDPWVKGMG WKKGEIAPQK CYVDSIEAWS
     CNECTINWNA SLAWLTAFSA LNADIKPGEG GKDIGKENNG GDAEPAEKST YDEEKADKNK
     AENKTKKSAS DDDENTDANT KENIKAGSDS KILFIGLIAG AVIILVVATE IFIYKMTKLK
     MQNQNKE
//
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