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Database: UniProt
Entry: E6UG31_RUMA7
LinkDB: E6UG31_RUMA7
Original site: E6UG31_RUMA7 
ID   E6UG31_RUMA7            Unreviewed;       995 AA.
AC   E6UG31;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   27-SEP-2017, entry version 46.
DE   RecName: Full=Endoglucanase {ECO:0000256|RuleBase:RU361166};
DE            EC=3.2.1.4 {ECO:0000256|RuleBase:RU361166};
DE   Flags: Precursor;
GN   OrderedLocusNames=Rumal_0505 {ECO:0000313|EMBL:ADU21058.1};
OS   Ruminococcus albus (strain ATCC 27210 / DSM 20455 / JCM 14654 / NCDO
OS   2250 / 7).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae;
OC   Ruminococcus.
OX   NCBI_TaxID=697329 {ECO:0000313|EMBL:ADU21058.1, ECO:0000313|Proteomes:UP000006919};
RN   [1] {ECO:0000313|EMBL:ADU21058.1, ECO:0000313|Proteomes:UP000006919}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27210 / DSM 20455 / JCM 14654 / NCDO 2250 / 7
RC   {ECO:0000313|Proteomes:UP000006919};
RX   PubMed=21914885; DOI=10.1128/JB.05621-11;
RA   Suen G., Stevenson D.M., Bruce D.C., Chertkov O., Copeland A.,
RA   Cheng J.F., Detter C., Detter J.C., Goodwin L.A., Han C.S.,
RA   Hauser L.J., Ivanova N.N., Kyrpides N.C., Land M.L., Lapidus A.,
RA   Lucas S., Ovchinnikova G., Pitluck S., Tapia R., Woyke T., Boyum J.,
RA   Mead D., Weimer P.J.;
RT   "Complete genome of the cellulolytic ruminal bacterium Ruminococcus
RT   albus 7.";
RL   J. Bacteriol. 193:5574-5575(2011).
CC   -!- CATALYTIC ACTIVITY: Endohydrolysis of (1->4)-beta-D-glucosidic
CC       linkages in cellulose, lichenin and cereal beta-D-glucans.
CC       {ECO:0000256|RuleBase:RU361166}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 9 (cellulase E)
CC       family. {ECO:0000256|RuleBase:RU361166}.
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DR   EMBL; CP002403; ADU21058.1; -; Genomic_DNA.
DR   RefSeq; WP_013497250.1; NZ_JHYT01000059.1.
DR   ProteinModelPortal; E6UG31; -.
DR   STRING; 697329.Rumal_0505; -.
DR   EnsemblBacteria; ADU21058; ADU21058; Rumal_0505.
DR   KEGG; ral:Rumal_0505; -.
DR   eggNOG; ENOG4105E08; Bacteria.
DR   eggNOG; ENOG410XNTA; LUCA.
DR   HOGENOM; HOG000245359; -.
DR   OMA; DERWIPL; -.
DR   OrthoDB; POG091H04TS; -.
DR   BioCyc; RALB697329:GIWQ-513-MONOMER; -.
DR   Proteomes; UP000006919; Chromosome.
DR   GO; GO:0008810; F:cellulase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030245; P:cellulose catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd02850; E_set_Cellulase_N; 1.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR008928; 6-hairpin_glycosidase-like.
DR   InterPro; IPR004197; Cellulase_Ig-like.
DR   InterPro; IPR003305; CenC_carb-bd.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR008979; Galactose-bd-like.
DR   InterPro; IPR001701; Glyco_hydro_9.
DR   InterPro; IPR033126; Glyco_hydro_9_Asp/Glu_AS.
DR   InterPro; IPR018221; Glyco_hydro_9_His_AS.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   Pfam; PF02018; CBM_4_9; 1.
DR   Pfam; PF02927; CelD_N; 1.
DR   Pfam; PF00759; Glyco_hydro_9; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00592; GLYCOSYL_HYDROL_F9_1; 1.
DR   PROSITE; PS00698; GLYCOSYL_HYDROL_F9_2; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|RuleBase:RU361166};
KW   Cellulose degradation {ECO:0000256|RuleBase:RU361166};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006919};
KW   Glycosidase {ECO:0000256|RuleBase:RU361166};
KW   Hydrolase {ECO:0000256|RuleBase:RU361166,
KW   ECO:0000313|EMBL:ADU21058.1};
KW   Polysaccharide degradation {ECO:0000256|RuleBase:RU361166};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006919};
KW   Signal {ECO:0000256|RuleBase:RU361166}.
FT   SIGNAL        1     32       {ECO:0000256|RuleBase:RU361166}.
FT   CHAIN        33    995       Endoglucanase. {ECO:0000256|RuleBase:
FT                                RU361166}.
FT                                /FTId=PRO_5005128274.
FT   DOMAIN       36    137       CBM-cenC. {ECO:0000259|Pfam:PF02018}.
FT   DOMAIN      220    322       CelD_N. {ECO:0000259|Pfam:PF02927}.
SQ   SEQUENCE   995 AA;  111537 MW;  073A3C73443F44B9 CRC64;
     MQMTMKRIAA GLVAITGALS ATAASAPMSV FAEDEQILIQ SDFDEGIGLP WYTTENAPAR
     QDFDISDGTY TVTILNNDGP ESRWDLQLGY RNFVIKKGHT YKVHWKVNSS NEGEMYTQIG
     NYSGTVEAWH NNCGNDDFNQ TWDCVQIAKG DNVFDAEFTA KEDIGRAEWV FQYGGNGMFQ
     DVDCFPNGTV LKFDDLSLID TTPGGCITEI KNNEWGVVRP ESNVRLNQIG YYPQLEKRAS
     YVTDASSPLQ FEIRDKNGNV KYTGTTKVFG SDPDSGTGKT TTVKIGSQIV TRLKDSGSNV
     HIIDFSDFRT EGEYTIFVKD TVGVSGTQVL LNNGANDTRL SGDKLLWTNP VTMKTYTMNE
     SSTFRIDRQI YDDQLLRDSM NYFYQNRSGV PIESEYITSG DKSALAHSRY GHNPDMAYVQ
     SKWFKSYDSD FRDGEKNEQI DVTGGWYAAN DHGKYVVEGG FSVWTLQNAY EFSKKSGNSH
     KWTNGTIAVP ENKDNAPDIL DEARVELEWM FKMINEDGFV YHSVQDHKWA GFPITPWMDD
     TQQGFEPVRI VRPPTYAATF NMIACAAQAS RLWKGIDDDF SKECLQNAQN SWKAIMAKQS
     KWDVKRGYHY SDPYFAPSEF GVNNIFGDNY VVDDAYWAAC ELYATTGDSA YYDFLKDNDQ
     SGQDKAFSLT SCLSGGENDR SFGSFNWGNT AGLGTLSLYL SDKTSSADRK TIANSIQNIA
     DQYLIQMSNE GMGIPYKSMT TEDYIGSDKP AFTGYEYGSN SFVINNAMVL AYAYDTDNSK
     YIYRNGAAEA LDYLFGRNGL GFSYVSGYGD KAMKSPHHRY WANSIDPDFP KAPSGVLAGG
     PCSDMYHDNY LRGLGYKRGT LADQKYYVDS AEAWTVNEVS VSLNASLVWM SSFMNDQFGG
     PKPVPYPTNI KVDYSEEYHQ VRFTWDKVEN ADRYGIAVYL AGKWRVQKQD ITGTTYTSPK
     NLTPGVTYKV AIAARVNGRW DTENAIKRAC TVTIK
//
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